BookGirija Prasad Rath, editor.
Summary: The book provides an excellent review of all the clinical aspects of neuroanesthesia in children, including neurosurgeries during fetal state to neonatal, infancy, toddler, and school-going age groups. To provide optimal anesthetic care in children undergoing neurosurgery, the care provider must have adequate knowledge on the developing brain and spinal cord, and the effect of anesthetics on the neuronal tissue, and the inherent issues pertaining to neurologic lesions. This book covers the diagnostic, imaging, surgical as well as anesthetic managements of all the neurosurgical problems in children. The chapters include a wide range of topics from basic neurophysiology to general concerns for pediatric neuroanesthesia, including fluid management, blood transfusion, temperature regulation, and surgical positioning, as well as specific issues such as anesthesia for brain tumor surgery, hydrocephalus, neural tube defects, cerebrovascular surgeries such as aneurysmal surgery, arteriovenous malformations (AVMs), Moyamoya disease, and vein of Galen malformation, functional neurosurgery, epilepsy surgery, neuroendoscopy, craniovertebral junction anomalies, spinal surgeries, neurotrauma, and brain abscess with congenital heart diseases. Interesting topics like neuroanesthesia in remote locations, regional anesthesia during neurosurgery, and anesthesia for children with neuromuscular disease are also discussed. Moreover, the book elaborates on advanced neuroanesthesia techniques during fetal neurosurgery and craniopagus separation surgery; and the postoperative intensive care management aspects in each chapter. This book caters to neuroanesthesiologists, pediatric anesthesiologists, residents, and fellows of anesthesia or neuroanesthesia, practicing anesthesiologists, pediatric neurointensivists, nurse anesthetists, neurosurgeons, and pediatric neurosurgeons. It also serves as a reference book for the DM (neuroanesthesiology and neurocritical care), DNB-SS (neuroanesthesiology), and MD (anesthesiology) curriculums apart from anesthesia residency and pediatric anesthesia/ neurosurgery fellowship programs offered at various Institutions worldwide.
Contents:
Intro
Foreword
Preface
Acknowledgments
Contents
About the Editor
Part I: General Considerations
1: Pediatric Neuroanesthesia: Evolution of a New Subspeciality
1.1 Introduction
1.2 Development of Neuroanesthesia Along with Neurosurgery
1.3 Development of Pediatric Neurosurgery as a Subspecialty
1.3.1 Neurosurgery: An Indian Perspective
1.4 Pediatric Neuroanesthesia: Not Just "Anesthesia" or "Neuroanesthesia"
1.5 Future Prospects as a Subspeciality
1.6 Conclusion
References 2: Developmental Anatomy and Physiology of the Central Nervous System in Children
2.1 Introduction
2.2 Development of the Central and Autonomic Nervous Systems
2.2.1 Intrauterine Development
2.2.2 Development of the Brain
2.2.3 Development of the Spinal Cord
2.2.4 Autonomic Nervous System (ANS)
2.2.5 Neuronal and Cellular Proliferation
2.2.6 Myelination
2.3 Relevant Anatomy
2.3.1 Head Size, Suture, and Fontanelle
2.4 Cerebral Vascular Anatomy
2.4.1 Arterial Circulation
2.4.2 Venous Drainage
2.5 Cerebral Physiology 2.5.1 Cerebral Blood Flow (CBF)
2.5.1.1 Factors Affecting Cerebral Blood Flow
Cerebrovascular Reactivity to Carbon Dioxide in Children
2.5.2 Cerebral Metabolic Rate (CMR)
2.5.3 Cerebral Autoregulation (CA)
2.5.3.1 Cerebral Autoregulation (CA) in Neonates
2.5.3.2 Cerebral Autoregulation (CA) in Small Children
2.5.4 Cerebral Spinal Fluid (CSF) Dynamics
2.5.5 Blood-Brain Barrier (BBB)
2.5.6 Intracranial Pressure (ICP)
2.5.7 Cerebral Compliance (Intracranial Pressure-Volume Relationship)
2.5.7.1 Intracranial Compliance 2.6 Spinal Cord Anatomy and Physiology
2.6.1 Spinal Cord Vascular Anatomy
2.7 Neurotoxicity in the Immature Human Brain
2.8 Epileptogenesis in the Developing Brain
2.9 Neuroprotection
2.9.1 General Measures
2.9.2 Anesthetic Agents
2.9.3 Temperature Control: Therapeutic Hypothermia
2.9.4 Hypoxic-Ischemic Preconditioning
2.9.5 Remote Ischemic Preconditioning
2.9.6 Erythropoietin (EPO)
2.9.7 Progesterone
2.9.8 Neurotrophic Factors
2.9.9 Stem Cell Treatment
2.10 Cerebral Physiology in Pathological States
2.11 Conclusion
References 3: Effect of Sedatives and Anesthetics on Cerebral Physiology in Children
3.1 Introduction
3.2 Effect of Specific Anesthetic Agents
3.2.1 Inhaled Anesthetics
3.2.1.1 Nitrous Oxide
3.2.1.2 Halothane
3.2.1.3 Isoflurane
3.2.1.4 Sevoflurane
3.2.1.5 Desflurane
3.2.1.6 Xenon
3.2.2 Intravenous Anesthetics
3.2.2.1 Propofol
3.2.2.2 Thiopentone
3.2.2.3 Etomidate
3.2.2.4 Ketamine
3.2.3 Other Agents
3.2.3.1 Opioids
3.2.3.2 Benzodiazepines
3.2.3.3 Muscle Relaxants
3.2.3.4 Dexmedetomidine
3.3 Anesthetic Neuroprotection in Children
3.4 Conclusion.