BookKenji Kabashima, Gyohei Egawa, editors.
Summary: This book sheds new light on "inducible" lymphoid organs (ILOs): antigen presentation sites that are generated de novo in peripheral tissues under various pathogenic conditions. Accomplished immunologists demonstrate that the physiological role of these ILOs is completely different from that of central lymphoid organs, i.e., the lymph nodes or spleen. In addition to the central organs, the ILOs are considered essential structures for the efficient elicitation of adaptive immune responses in lesions. The respective chapters highlight examples from multiple sites, e.g. the skin, lung, intestinal tract, genital tract, the synovial membrane of the joints and artificial lymph nodes. Accordingly, readers will learn that ILO structure and function can vary substantially, depending on the context. Presenting the results of the latest immunological research, the book offers a fascinating and insightful read for both scientists and clinicians in the areas of infectious and immune-associated diseases.
Contents:
Basics of Inducible Lymphoid Organs
Role of iBALT in respiratory immunity
Chronic inflammation in mucosal tissues: Barrier integrity, inducible lymphoid tissues, and immune surveillance
Role of lymphoid structure in skin immunity
Memory lymphocyte clusters in genital immunity: Role of tissue-resident memory T cells (TRM)
Ectopic lymphoid tissue in Rheumatoid Arthritis
Artificial construction of immune tissues/organoids and their application for immunological intervention.
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