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  • Book
    Patricia Silveyra, Xenia T. Tigno, editors.
    Summary: This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lungs innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.

    About This Book
    About the Editors
    Chapter 1: Sex Differences in Respiratory Physiology
    1.1 Introduction
    1.2 Historical Studies of Sex Differences
    1.3 Definitions and Methods to Assess Respiratory Structure/Function
    1.4 Sex Differences in the Developing Lung
    1.5 Peri-Pubertal Sex Differences and Adulthood
    1.6 Importance of Sex Differences in the Lung
    Chapter 2: Sex Differences in the Anatomy of the Airways and the Lungs: Impact on Dysanapsis across the Lifespan 2.1 Introduction
    2.1.1 Anatomical Overview of Airways and Lungs Airways Lung
    2.2 Determinants of Sex Differences in the Airways, the Lungs, and dysanapsis
    2.2.1 Dimensional Determinants Nasopharynx Pharynx Glottis Vocal Cords Larynx Trachea and Main Bronchi
    2.2.2 Lung
    2.3 Dysanapsis
    2.4 Immunological Determinants
    2.5 Hormonal Determinants
    2.6 Conclusion
    Chapter 3: Sex Steroids and Their Influence in Lung Diseases Across the Lifespan
    3.1 Introduction 3.2 Biology of Sex Steroids
    3.2.1 Estrogen
    3.2.2 Progesterone
    3.2.3 Testosterone
    3.2.4 Other Regulators of Sex Steroids
    3.3 Functions of Sex Steroids Across the Lifespan: An Emphasis on Lung Diseases
    3.3.1 Effects of Sex Steroids in Prenatal Lungs
    3.3.2 Effects of Sex Steroids in Early Childhood
    3.3.3 Effects of Sex Steroids in Late Childhood/Puberty
    3.3.4 Effects of Sex Steroids in Adult Lungs
    3.3.5 Effects of Sex Steroids in Aging Lungs
    3.4 Conclusion and Future Scope
    Chapter 4: Sex Differences in the Developing Lung: Implications for Disease 4.1 Introduction
    4.2 Neonatal Lung
    4.2.1 Lung Development During Gestation and Infancy
    4.2.2 Gender Disparities in Preterm Neonatal Outcomes
    4.2.3 Gender and Respiratory Outcomes in Preterm Infants Respiratory Distress Syndrome (RDS) Bronchopulmonary Dysplasia (BPD) Sex-specific Response to Environmental Smoking Exposures Chronic Cough Protracted (or Persistent) Bacterial Bronchitis (PBB) Primary Ciliary Dyskinesia (PCD) Non-cystic Fibrosis (Non-CF) Bronchiectasis Cystic Fibrosis (CF) 4.3 Prepubertal Development of the Lung
    4.3.1 Lung Development During Early Childhood
    4.3.2 Pulmonary Function Testing in Infants and Preschool Children Forced Deflation and the Rapid Thoracoabdominal Compression Measures of Compliance and Resistance Forced Oscillation Technique (FOT) Inert Gas Washout (IGW) Electrical Impedance Tomography (EIT) Ventilator Graphics
    4.3.3 Pulmonary Function Testing in Older Children Spirometry
    4.3.4 Sex Differences in Airway Obstruction and Lung Diseases
    Digital Access Springer 2021