BookCanhua Huang, Yuanyuan Zhang, editors.
Summary: This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.
Contents:
Oxidative stress and anti-oxidant strategies in human diseases
Oxidative stress in the tumorimmune microenvironment
Oxidative stress-mediated stem cell aging
Stress proteins: Biological functions, human diseases and virus infections
Importance of mitochondrial quality controls in Parkinsons disease: the potential interplay of mitochondrial unfolded protein response and mitophagy
Autophagy in cellular stress responses
Cysteine metabolism in cancer progression and therapy resistance
Stress and circadians
ROS, glucose and lipid metabolism
Drug repurposing: An avenue towards stress medicine in cancer therapy
Redox regulation of metabolic enzymes in cancer
Stress and inflammation
Oxidative stress in cell signaling and cell fate determination under glucose starvation.