BookJun Sun, editor.
Summary: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
Contents:
Chapter 1: The Microbiome And The Hallmarks Of Cancer
Chapter 2: Microbiome In Human GI Cancers
Chapter 3: The Gut Microbiome And Colorectal Cancer
Chapter 4: Salmonella Infection In Human Cancers
Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions
Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment
Chapter 7: Microbiome And Liver Cancer
Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS
Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer
Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease
Chapter 11: Dietary And Microbiome In Cancer Prevention
Chapter 12: Autophagy And Cancer-Current Biology And Drug Development
Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer
Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing 'Human Microbiome' Market
Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota
Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.