BookJonathan A. Bernstein, editor.
Summary: This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.
Contents:
Chapter 1. Overview of Immunodeficiency
Part I. B-Lymphocyte Immunodeficiency
Chapter 2. Common Variable Immunodeficiency, Hypogammaglobulinemia, and Specific Antibody Deficiency
Chapter 3. Agammaglobulinemia
Chapter 4. Class Switch Defects
Chapter 5. Transient Immunodeficiency of Infancy
Chapter 6. Selective Isotype Immunodeficiency
Chapter 7. Common Variable Immunodeficiency Disorders-like Disorders
Part II. T-Cell Immunodeficiency
Chapter 8. Severe Combined Immunodeficiency
Chapter 9. Idiopathic CD4 Lymphopenia
Chapter 10. Hyper IgE Syndrome
Chapter 11. Genetic Syndromes with Associated Immunodeficiencies
Part III. Immune Dysregulation Syndromes
Chapter 12. Autoimmune Lymphoproliferative Syndrome
Chapter 13. Auto-inflammatory Syndromes
Chapter 14. Immune Dysregulation Leading to Autoimmunity
Chapter 15. Dendritic Cells in Primary Immunodeficiency
Part IV. Innate Immune Defects
Chapter 16. Congenital Neutropenia and Migration Defects
Chapter 17. Chronic Granulomatous Disease
Chapter 18. Primary Immunodeficiencies of Complement
Chapter 19. Natural Killer Cell Defects
Chapter 20. Mucocutaneous Candidiasis
Part V. Secondary Immunodeficiency
Chapter 21. Immunodeficiency Secondary to Malignancies and Biologics
Chapter 22. Immunodeficiency Secondary to Prematurity, Pregnancy, and Aging
Chapter 23. Vaccinations in Primary and Secondary Immunodeficiencies Including Asplenia.