BookAbialbon Paul, Nishanthi Anandabaskar, Jayanthi Mathaiyan, Gerard Marshall Raj, editors.
Springer Nature eBook.
Summary: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. .
Contents:
Intro
Foreword
Preface
Preface to Volume 1: General and Molecular Pharmacology: Principles of Drug Action (https://link.springer.com/book/10.1007/978...
Acknowledgments
Contents
Editors and Contributors
Part I: Autonomic Nervous System
1: Cholinoceptor Agonists and Anticholinesterase Agents
1.1 Introduction
1.2 Synthesis and Degradation of ACh
1.3 Cholinergic Receptors
1.4 Action of ACh in Different Organ Systems
1.4.1 Central Nervous System
1.4.2 Heart
1.4.3 Blood Vessels
1.4.4 Lungs
1.4.5 Gastrointestinal Tract
1.4.6 Urinary Tract 1.4.7 Eye
1.4.8 Glands
1.4.9 Skeletal Muscles
1.4.10 Ganglion
1.5 Cholinomimetic Drugs
1.5.1 Classification
1.5.2 Direct Muscarinic Agonists
1.5.3 Toxicology of Muscarinic Alkaloids
1.5.4 AChE and Anticholinesterases
1.5.5 Pharmacological Actions of Anticholinesterases
1.5.6 Therapeutic Uses of Anticholinesterases
1.6 Toxicology of Anticholinesterases: Management of OPC and Carbamate Poisoning
1.6.1 Acute Organophosphorus Poisoning
1.6.2 Acute Carbamate Poisoning
1.6.3 Intermediate Syndrome in OPC Poisoning
1.6.4 Delayed Neuropathy in OPC Poisoning 2.6.5 Bronchial Asthma and COPD
2.6.6 Motion Sickness
2.6.7 Arrhythmias
2.6.8 Drug-Induced Parkinsonism
2.6.9 In Poisoning
2.6.10 Other Uses with Unproven Efficacy
2.7 Adverse Effects and Contraindications
2.8 Management of Anticholinergic Poisoning
2.9 Ganglion Blockers
Bibliography
3: Adrenergic Agonists
3.1 Organ Specific Effects of Adrenergic Agonists
3.1.1 Cardiovascular System
3.1.1.1 Effect of the Alpha 1 Receptor Activation
Vascular Tone
Cardiac Parameters
Blood Pressure
3.1.1.2 Effect of Alpha 2 Receptor Activation
Peripheral Action Central Action
3.1.1.3 Effect of Beta 1 Receptor Activation
Cardiac Parameters
3.1.1.4 Effect of Beta 2 Receptor Activation
3.1.1.5 Effect of Dopamine Receptor Activation
3.1.2 Effects on Other Organ Systems (Box 3.1)
Box 3.1 Effects on Other Organ Systems
3.2 Sympathomimetic Drugs
3.2.1 Endogenous Catecholamines
3.2.1.1 Epinephrine
Pharmacokinetics
Mechanisms of Action on Various Organ Systems and Uses of Epinephrine
Adverse Drug Reactions
Uses of Epinephrine
3.2.1.2 Norepinephrine
Cardiovascular System
Adverse Drug Reactions
Therapeutic Uses