BookJoseph F. Goldberg, Stephen M. Stahl ; foreword by Alan F. Schatzberg.
Summary: "The impetus for this book comes from our perception of a distinct unmet need in the world of clinical psychopharmacology, that of a marriage between clinical neuroscience and evidence-based trials, brokered by the matchmaker of pragmatism. There is, on the one hand, an ever-growing literature of randomized controlled trials, crossover trials, open case series, proof of concept studies and case reports that lend varying degrees of support for innovative therapeutic strategies; and, on the other hand, there exists a clinical reality in which patients frequently start and stop drugs not always for compelling reasons, where everyday practitioners manage patients on extensive polypharmacy regimens that may at times look like random assemblages, pharmacodynamic rationales are not always purposeful, mechanisms of action can be unwittingly redundant or contradictory, and ineffective treatments may senselessly get retained (sometimes perhaps even hoarded) rather than deprescribed"-- Provided by publisher.
Contents:
Core Concepts of Good Psychopharmacology
Targets of Treatment : Categories versus Dimensions of Psychopathology
Interpreting and Using the Literature : Integrating Evidence-Based Trials with Real World Practice
Placebo and Nocebo Effects
Tailoring the Fit : Moderators and Mediators of Treatment Outcome
Complex Regimens and Rationale-Based Combination Drug Therapies
Laboratory Values and Psychiatric Symptoms : What to Measure, What Not to Measure, and What to Do With The Results
Pharmacogenetics : When Relevant, When Not
Cross-tapering and the Logistics of Drug Discontinuation
Managing Major Adverse Drug Effects : When to Avoid, Switch, or Treat Through
Novel Drug Therapeutics : Nutraceuticals, Steroids, Probiotics, and Other Dietary Supplements
Human Diversity and Considerations in Special Populations
Disordered Mood and Affect
Disorders of Impulsivity, Compulsivity, and Aggression
Psychosis
Deficit States and Negative Symptoms
Anxiety
Addiction and the Reward Pathway
Trauma and Posttraumatic Stress Disorder
Personality Disorders
Cognition
Putting it All Together.