BookVikas R. Dharnidharka, Michael Green, Steven A. Webber, Ralf Ulrich Trappe, editors.
Summary: This disorder transcends multiple disciplines and demands a team approach to improve knowledge and treatment. The highly experienced internationally recognized authors have updated every section and added many new chapters, including some on genetic abnormalities in virus and host seen in PTLDs. In this successor edition, there is a completely new section on PTLDs after hematopoietic stem cell transplantation. The newest PTLD classifications and current treatment paradigms that reflect recently conducted international trials are fully incorporated. As technologies have advanced, this book provided state-of-the-art new diagnostic and prognostic information. Post-Transplant Lymphoproliferative Disorders 2nd Edition is designed to be a valuable reference for oncologists and all transplant professionals, such as surgeons, nephrologists, cardiologists, hepatologists/gastroenterologists, pulmonologists, infectious disease specialists, pathologists, as well as interns and residents in training in these specialists. It provides these professionals with comprehensive and up-to-date information that guides their management of transplant patients before and after transplant, with and without PTLD. .
Contents:
Introduction and History
Definitions and Pathology of PTLD
EBV Biology in the Pathogenesis of PTLD
Host genetic mutations and expression analyses in PTLD
Immune responses to EBV in the immunocompromised host
Technical aspects of Epstein-Barr viral load assays
Epidemiology of PTLD after SOT
Clinical Features and Diagnostic Considerations
Prognostic Factors
Management of PTLD
Prevention of Epstein - Barr virus Infection and Post-Transplant Lymphoproliferative Disorders Following Transplantation
Epidemiology and Prognosis of PTLD after HSCT
Clinical Presentations and Features of PTLD after Hematopoietic Stem Cell Transplantation
Management of PTLD after HSCT
Preventative and preemptive strategies for EBV infection and PTLD after hematopoietic stem cell transplantation
Organ Specific issues of PTLD Kidney
Liver
Post-transplantation Lymphoproliferative Disorder in Intestinal Transplant Recipients
PTLD After Heart Transplantation
Lung Transplantation
Research Priorities and Future Directions.