BookAyse Basak Engin, Atilla Engin, editors.
Summary: "Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life"--Publisher's description.
Contents:
Protein kinase-mediated decision between the life and death
Aging and protein kinases
The connection between cell fate and telomere
Dark-side of exosomes
Signal transduction in immune cells and protein kinases
Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity
Combined toxicity of metal nanoparticles: comparison of individual and mixture particles effect
Protein kinases signaling in pancreatic beta-cells death and type diabetes
Bile acid toxicity and protein kinases
N-Methyl-D-aspartate receptor signaling-protein kinases crosstalk in cerebral ischemia
Alzheimer’s disease and protein kinases
Bacterial protein kinases
Indoleamine 2,3-dioxygenase activity-induced acceleration of tumor growth, and protein kinases-related novel therapeutics regimens
A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy
Protein kinases in hematological disorders
Metabolic stress and immunity: nutrient-sensing kinases and tryptophan metabolism.