Bookedited by Frederick J. Suchy, Ronald J. Sokol, William F. Balistreri, Jorge A. Bezerra, Cara L. Mack, Benjamin L. Shneider.
Summary: "The essential liver endocrine and exocrine functions require a precise spatial arrangement of the repeated hepatic lobule consisting of the central vein, portal vein, hepatic artery, intrahepatic bile duct system, and hepatocyte zonation. This allows 1. blood to be carried through the liver parenchyma and sampled by all hepatocytes, 2. hepatocytes to uptake metabolites and toxins from the blood for metabolizing and detoxification from their basal sinusoidal side, and 3. hepatocytes to produce and secrete bile from their apical canalicular side to be carried out of the liver through the biliary (i.e., intrahepatic bile duct) system composed of biliary epithelial cells (i.e., cholangiocytes)"-- Provided by publisher.