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  • Book
    Pradip P. Kamat, John W. Berkenbosch, editors.
    Summary: This book provides a comprehensive overview on sedation and analgesia for the pediatric intensivist. Divided into two primary sections, the text presents a framework on how to care for patients who need sedation, analgesia, and neuromuscular blockade inside the pediatric ICU (PICU), and how to manage procedural sedation in an outpatient setting. The first section focuses on sedation and analgesia for the critically ill child, with an emphasis on analgesics, sedatives, neuromuscular blockade, tolerance and withdrawal, and the PICU environment. The second section centers around procedural sedation, detailing patient selection, pre-sedation assessment, how to choose a sedation regimen, available agents, and nursing considerations. Written by experts in the field, Sedation and Analgesia for the Pediatric Intensivist: A Clinical Guide is a valuable resource for the pediatric intensivist in caring for their patients both inside and outside the PICU.

    Contents:
    Intro
    Foreword
    Preface
    Contents
    Contributors
    Part I: Sedation and Analgesia for the Critically Ill Child
    Chapter 1: Introduction to Sedation and Analgesia
    Brief History of Pediatric Sedation and Analgesia
    Goal of Sedation and Analgesia in the Critically Ill Child
    Physiology of Pain
    Complexities of Sedation and Analgesia in the Critically Ill Child
    References
    Chapter 2: Safety and Monitoring During Pediatric ICU Sedation
    Assessment Tools
    Pain Assessment
    Self-Report Tools and Surrogate Reporting
    Observational Tools Agitation and Sedation Assessment
    Objective Monitoring Tools
    Processed EEG
    Conventional EEG
    Conclusions
    References
    Chapter 3: Analgesic Use in the Pediatric Intensive Care Unit
    Specific Agents
    References
    Chapter 4: Regional Analgesia and Its Role in the PICU
    Introduction
    History
    Safety and Risks of Regional Anesthesia
    Benefits of Regional Anesthesia
    Some Common Blocks
    Central Neuraxial Blocks
    Upper Extremity Blocks
    Truncal Blocks
    Lower Extremity Blocks
    Conclusion
    References
    Part II: Sedative Agents Chapter 5: Sedative Agents (Benzodiazepines)
    Overview of Benzodiazepines and Mechanism of Action
    Pharmacokinetic and Pharmacodynamic Considerations
    Adverse Reactions, Drug-Drug Interactions, and Monitoring Parameters
    Benzodiazepine and Opioids
    Breastfeeding/Pregnancy Considerations
    Pregnancy Considerations
    Breastfeeding Considerations
    In Summary
    References
    Chapter 6: Alpha-Agonists in Pediatric Critical Care
    Introduction
    Pharmacology
    Clinical Applications
    Conclusion
    References
    Chapter 7: Barbiturates in the Pediatric ICU
    Introduction Pharmacology
    Clinical Applications
    References
    Part III: Anesthetic Agents
    Chapter 8: Sedation and Analgesia for the Critically Ill Child: Ketamine
    Introduction
    Pharmacokinetics and Pharmacodynamics
    Mechanism of Action
    Dosing
    Uses of Ketamine in the Pediatric Intensive Care Unit
    Ketamine for Sedation
    Ketamine for Acute Pain
    Ketamine for Chronic Pain
    Ketamine Side Effects
    Conclusion
    References
    Chapter 9: Propofol for Sedation of the Critically Ill Child
    Introduction
    Pharmacology
    Mechanism of Action
    Pharmacokinetics
    Pharmacodynamics Clinical Considerations for Use
    Indications for Short-Term, Deep Sedation
    Propofol "Drug Washout"
    The Impact of Propofol on Sleep and Delirium in ICU Patients
    Palliative Sedation
    Propofol-Related Infusion Syndrome (PRIS)
    Pathophysiology
    Prevention and Treatment
    Consideration in Special Populations
    Mitochondrial and Metabolic Disorders
    Conclusions
    Bibliography
    Chapter 10: Inhalational Agents: What Volatile Inhalational Agents Are and How to Use Them in the ICU Setting
    Introduction
    Principles of Inhalational Agents
    Minimum Alveolar Concentration
    Digital Access Springer 2021