BookStefano Govoni, Pierluigi Politi, Emilio Vanoli, editors.
Summary: Back Cover Text. This ambitious and comprehensive manual represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling. Written by leading international experts in their respective research areas, it presents a variety of perspectives on the core topic: from social and philosophical to gender-related aspects. Designed for a broad readership, it includes dedicated sections for cardiologists, psychiatrists, neurologists and psychotherapists looking for a more insightful and targeted approach to neuro-cardiovascular disease.
Contents:
Intro
Preface
Acknowledgments
Contents
About the Editors
About the Section Ediotrs
Contributors
Part I: Functional Anatomy and Molecular Basis of the Cardiac-Brain Axis
1 Brain-Heart Afferent-Efferent Traffic
Introduction: Overview of Cardiac Neuronal Control
Structural and Functional Organization of the Cardiac Nervous System: Peripheral Signaling
Cardiac Afferent Neurons
Nodose Ganglion Cardiac Afferent Neurons
Dorsal Root Ganglion Cardiac Afferent Neurons Cardiovascular Afferent Neurons in Intrathoracic Extracardiac Ganglia and in Ganglionated Plexi
Cardiac Motor Neurons
Cardiac Sympathetic Efferent Neurons
Cardiac Parasympathetic Efferent Neurons
Local Circuit Neurons
Structural and Functional Organization of the Cardiac Nervous System: Central Signaling
Neuraxial Transduction of Cardiac Pathology
Neuraxial Transduction of Myocardial Ischemia and Infarction
Neuraxial Transduction in Heart Failure
Concluding Summary
Cross-References
References
2 Brain-Heart Communication
Introduction Evidence of Heart-Brain Interactions: The Hardware
The Signaling Pathways: The Software
Reflexes and Modulators: A Complex Network Affecting Cardiac Function
The Baroreceptor Reflex
Adrenaline
Angiotensin II
Natriuretic Peptides
Neurotrophins
Conclusions
Cross-References
References
3 The Cardiorenal Cross Talk
Introduction
Measurements of Autonomic Nervous System Activity
Sympathetic Innervation of the Kidney
The Sympathorenal Axis in Heart Failure Consequences of Neurohormonal Axis Activation and Fluid Retention in the Circulatory System, in the Kidney Function, and in th...
Conclusion
References
4 Genetic Determinants Affecting the Relationship Between the Autonomic Nervous System and Sudden Death
Introduction
Neurocardiac Interactions and Ventricular Arrhythmogenesis
Anatomy
Physiology
Role in Ventricular Arrhythmogenesis
Genetic Determinants of Autonomic Nervous System Remodeling
Altered Innervation
Variants in Human Adrenergic Receptors
Altered Autonomic Nervous System in Neuronal Disease Sudden Infant Death Syndrome
Sudden Unexpected Death in Epilepsy
Small Fiber Neuropathy
Genetic Determinants of Inherited Arrhythmia Syndromes Susceptible to Autonomic Nervous System Triggering
Long QT Syndrome
Catecholaminergic Polymorphic Ventricular Tachycardia
Brugada Syndrome
Takotsubo Cardiomyopathy
Sudden Cardiac Death in General Population
Conclusion
References
5 Cognitive Decline in Elderly Patients with Hypertensive Heart Disease
Introduction
Hypertension and Hypertensive Heart Disease in the Elderly