BookJoginder Singh, Vineet Meshram, Mahiti Gupta, editors.
Summary: This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the books closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the books goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.
Contents:
Intro
Preface
Contents
About the Editors
Part I: Plants Natural Products: Fountainheads for Drug Discovery and Development
1: The Artemisia Genus: Panacea to Several Maladies
1.1 Introduction
1.2 Phytochemistry
1.3 Conservation of Artemisia Species
1.4 Conclusions
References
2: Bacopa monnieri: The Neuroprotective Elixir from the East-Phytochemistry, Pharmacology, and Biotechnological Improvement
2.1 Introduction
2.2 Methodology
2.3 Bioactivity Study
2.3.1 Biological Activities of Plant Extract(s)
2.3.1.1 Pro-cognitive Activity 2.3.1.2 Anti-neurodegenerative Activity
2.3.1.3 Antidepressant and Anti-stress Activity
2.3.1.4 Neuroprotective Activity
2.3.1.5 Cardioprotection
2.3.1.6 Gastrointestinal and Hepatoprotective Activity
2.3.1.7 Antiemetic Activity
2.3.1.8 Anti-epileptic Activity
2.3.1.9 Antioxidant Activity
2.3.1.10 Miscellaneous Activity
2.3.2 Pharmacological Activity of the Active Compounds
2.3.2.1 Bacoside A
Anti-Alzheimerś Activity
Anti-apoptotic Activity
Anti-epileptic Activity
Antidepressant Activity
Anti-dopaminergic Activity
Anti-inflammatory Activity 3.5.9 Immunomodulatory Properties
3.5.10 Neuroprotective Activity
3.5.11 Cardioprotective Activity
3.6 Phytochemistry of Cinnamon
3.7 Clinical Study Based on Cinnamon
3.8 Extraction and Isolation of Bioactive Phytochemicals
3.9 Biotechnological Techniques for Large-Scale Multiplication of Cinnamomum Species
3.10 Molecular Markers for Genetic Diversity Assessment of Cinnamomum Species
3.11 Discussion and Conclusion
References
4: Swertia spp.: A Potential Source of High-Value Bioactive Components, Pharmacology, and Analytical Techniques
4.1 Introduction 3: Current Knowledge of Cinnamomum Species: A Review on the Bioactive Components, Pharmacological Properties, Analytical and B...
3.1 Introduction
3.2 Botanical Description
3.3 Distribution
3.4 Traditional Use and Polyherbal Formulation of Cinnamon
3.5 Pharmacological Property of Cinnamomum Species
3.5.1 Anti-inflammatory Activity
3.5.2 Antibacterial Activity
3.5.3 Antifungal Activity
3.5.4 Antiviral Activity
3.5.5 Antioxidant Activity
3.5.6 Anticancer Activity
3.5.7 Gastroprotective Activity
3.5.8 Hypoglycemic/Anti-lipidemic Activity Antioxidant Activity
Hepatoprotection
Neuroprotection
Protease Inhibition Activity
Renoprotective Activity
Wound-Healing Activity
2.3.2.2 Bacopaside I
2.3.2.3 Betulinic Acid
2.3.3 Pharmacological Activity of the Polyherbal Formulation(S)
2.3.3.1 Cognition
2.3.3.2 Hepatic Encephalopathy
2.4 Biotechnological Advancement
2.5 Toxicity Study
2.6 Drug Designing
2.7 Structure-Activity Relationship
2.8 Summary
2.9 Conclusion
References