BookMichael A. Nader, Yasmin L. Hurd, editors.
Summary: The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders. The first section is dedicated to methodology including population-based surveys, basic neuroanatomy, chemistry, molecular biology, behavioral models and brain imaging. The second section utilizes this methodology in research related to opioids, cocaine, marijuana, alcohol and nicotine. The book is aimed at both professionals (academics, clinicians, practitioners) and students or trainees.
Contents:
Intro
Preface
References
Contents
Methods for Population Research on Substance Use and Consequences
1 Introduction
2 Population Research on Substance Use and Consequences
2.1 Data Collection Methods
2.1.1 Surveys
2.1.2 Ecological Momentary Assessment
2.1.3 Administrative Data
2.1.4 Audit Methods
2.1.5 Unobtrusive Assessment of Substance Use
3 Measures
3.1 Measures of Own Use
3.1.1 Type of Substance
3.1.2 Mode of Consumption
3.1.3 Quantity and Frequency of Use
3.1.4 Setting
3.1.5 Source
3.1.6 Problems Associated with Use 3.2 Harming Others
4 Causal Factors and Correlates of Substance Use and Consequences
4.1 Individual Causal Factors and Correlates
4.1.1 Sociodemographic Factors
4.1.2 Sexual Orientation and Identity
4.1.3 Personality and Attitudinal Factors
4.1.4 Personality and Attitudinal Factors
4.1.5 Mental Health
4.2 Environmental Causal Factors and Correlates
4.2.1 Situational Factors
4.2.2 Family Factors
4.2.3 Peer Networks
4.2.4 Availability of Substances
4.2.5 Price
4.2.6 Marketing
4.2.7 Policy
4.2.8 Enforcement Practices
4.2.9 Community Characteristics 4.3 GWAS Identified a nAChR Subunit Risk Variant Associated with Nicotine Dependence
4.4 Molecular and Pharmacological Approaches Have Defined Roles for Genetic Polymorphisms in Substance Use Disorder Physiology
4.5 Animals: Behavioral Models of Substance Use Disorder
4.6 Use of Animal Models to Explore Genetic Polymorphisms Associated with Substance Use Disorder
4.7 Transcriptomics and Substance Use Disorder
4.8 Cell-Type Specificity: Single-Cell and FACS-Based Approaches
5 Epigenetic Components of SUD
5.1 Histone Modifications
5.2 DNA Methylation 5 Summary and Conclusion
5.1 Accumulation of Knowledge
5.2 Translation of Knowledge
5.3 Limitations
References
Translational Molecular Approaches in Substance Abuse Research
1 Introduction
2 The Neurobiology of Substance Use Disorder
3 Substance Use Disorder Heritability
4 Genetic Components of SUD
4.1 Consideration of SUD Phenotypes in Human Clinical Populations
4.2 Genome-Wide Associations and Functional Validation Studies Reveal Genetic Susceptibility and Neurobiological Mechanisms of... 5.3 Chromatin Structure
6 Conclusions and Future Directions
References
Small Molecule Neuropeptide S and Melanocortin 4 Receptor Ligands as Potential Treatments for Substance Use Disorders
1 SUDs Medications Development
2 Neuropeptide S (NPS)
2.1 Oxazolo[3,4-a]pyrazin-3-ones
2.2 Pyranopyrimidine Derivatives
2.3 Furo[3,4-c]pyridine Derivatives
2.4 Imidazopyridines
2.5 Quinolinone Derivatives
2.6 Tricyclic Imidazole Derivatives
2.7 Indan-1,3-dione and Indan-1-one Derivatives
2.8 Pyrroloimidazole Derivatives
3 Melanocortin 4 (MC4)
3.1 Spiropiperidines