BookBoris A. Shenderov, Alexander V. Sinitsa, Mikhail M. Zakharchenko, Christine Lang.
Summary: Aimed at students, researchers, nutritionists, and developers in food technology, this research text addresses the nascent field of metabiotics. Metabiotics are products based on components of cells, metabolites, and signaling molecules released by probiotic strains, engineered to optimize host-specific physiological functions in a way that traditional probiotics cannot. This book examines the history, processes, design, classifications, and functions of metabiotics. It includes an overview of the composition and function of the gut microbiota, and discusses development of target-specific metabiotics. Further coverage includes comparisons to traditional probiotics, as well as probiotic safety and side-effects. Metabiotics: Present State, Challenges and Perspectives provides a complete history and understanding of this new field, the next phase of the probiotic industry.
Contents:
Intro
Preface
Contents
About the Authors
Introduction
The Composition and Functions of Human Gut Symbiotic Microbiota
Contemporary Views on Biotechnological Potential of Symbiotic Microorganisms
The Digestive Function of Human Gut Microbiota
Metabolic Relationship Between the Host and Its Gut Microbiota
Factors and Agents that Modify the Composition and Functions of Symbiotic Microbiota
Diagnostic Methods for Microecological Imbalance and its Consequences Contemporary Microecological Strategies of Gut Microbiota Modulation for Human Health Preservation, Restoration and Improvement
Molecular Language of Symbiotic Gut Microorganisms
Drawbacks and Negative Consequences of Traditional Probiotics Based on Live Microorganisms
Metabiotics: New Stage of the Probiotic Concept Development
Methods and Techniques Used for Obtaining and Identifying of Microbial Low Molecular Weight Cellular Compounds, Metabolites and Signaling Molecules
Classification of Metabiotics and their Brief Description Some New Targets and Approaches to the Construction of Intended-Use Metabiotics
Modulators of QS-Regulation
Modulators of Immunity
Modulators of Energy Metabolism
Modulators of Antioxidant Status
Modulators of Intercellular Information Exchange
Modulators of Neuropsychic and Social Behavior
Modulators of Epigenome Regulation
Metabiotics on the Base of Microbial Gas Molecules
Hybrid Multicomponent Microbial Molecules as a Base for Metabiotics
Other Contemporary Examples of the Techniques Needed to Create, Maintain and Correct Human Microbial Ecology
Conclusion Some of the Best-known Metabiotics on the Market of Microecological Products
Cellular Metabiotics and Metabolite Metabiotics
Cellular Metabiotics
Helicobacter and Stomach Health
Probiotics in Helicobacter Therapy
The Helinorm/Pylopass Strategy
The Pylopass Strain
Characteristics of Pylopass
Cell Walls Exhibit the Co-Aggregation Sites
The Power of Metabiotic Formulation
Clinical Evaluation
Outlook
Metabolite Metabiotics
Clinical Assessment
Prospects in the Field of Intended-Use Metabiotics Creation