BookJames C. Bonner, Jared M. Brown, editors.
Summary: This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.
Contents:
Overview of immune response to nanomaterials caused by either inhalation, oral, or dermal exposure
Engineered nanomaterials: synthesis, characterization, uses and exposure
Impact of nanomaterials on barrier function
Complement activation and inflammation
Macrophage function and phagocytosis
Mast cells
Impact on dendritic cell
lymphocyte function
Impact on host pathogen response and microbiome
Allergy/autoimmunity
Pre-existing allergic or bacterial-induced lung disease
Nanomaterial effects on viral infection
Immunotoxicity and carcinogenesis
In vivo animal models (nude mice, transgenic models)
In vitro cell culture models
In silico computational modeling
Summary of mechanisms of immune modulation.