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  • Book
    Nosheen Masood, Saima Shakil Malik, editors.
    Summary: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

    Contents:
    1: Overview of Cancer Genomics, Organization, and Variations in the Human Genome
    2: Metabolic Changes and Their Characterization
    3: Unravelling the Genomic Targets of Small Molecules and Application of CRISPR-Cas 9 System for Genomic Editing in Cancer with Respective Clinical Applications
    4: Genome Editing in Cancer Research and Cure
    5: New Adsorption-Based Biosensors for Cancer Detections and Role of Nano-medicine in Its Prognosis and Inhibition
    6: Genomic Instability and Cancer Metastasis
    7: DNA Damage Response Pathways in Cancer Predisposition and Metastasis
    8: Adapting the Foreign Soil: Factors Promoting Tumor Metastasis
    9: MicroRNAs in Cancer: From Diagnosis to Therapeutics
    10: Metabolic and Enzyme Engineering for the Microbial Production of Anticancer Terpenoids
    11: Translational Research in Oncology
    12: Molecular Profiling of Breast Cancer in Clinical Trials: A Perspective
    13: Systems Biology and Integrated Computational Methods for Cancer-Associated Mutation Analysis
    14: Biostatistics in Clinical Oncology
    15: History of Drug Reaction in Children Suffering from Cancer
    16: Pharmacogenomics of Cisplatin-Induced Toxicity in Children
    17: Pharmacogenomics of Methotrexate-Induced Toxicity in Children
    18: Pharmacogenomics of Thiopurine-Induced Toxicity in Children
    19: Pharmacogenetics in Cancer Treatment: Challenges and Recent Trends
    20: Precision Nutraceutical Approaches for the Prevention and Management of Cancer
    21: Cancer Genomics in Precision Oncology: Applications, Challenges, and Prospects
    Digital Access Springer 2020
  • Article
    Krammer EB.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2507-11.
    Integration of our own morphological observations into recent ultrastructural, biochemical, and neuropharmacological results on the carotid body led to a new hypothesis on chemoreceptor function: (i) Glomus cells with small dense-cored vesicles (type IB cells) that store norepinephrine are chemoreceptors. (ii) Glomus cells with large dense-cored vesicles (type IA), which are postsynaptic to the other glomus cell type and presynaptic to afferent nerve endings, are dopaminergic interneurons that suppress the afferent discharge frequency during normoxia by releasing dopamine. (iii) The hypoxic stimulus causes the chemoreceptive cell to release the stored norepinephrine, which in turn brings about disinhibition of the afferent nerve endings by inhibition of the interneuron. (iv) Afferent nerve endings and interneurons interact through reciprocal synapses that form a short inhibitory feedback loop. We propose that information in the carotid body is processed in a fashion graded rather than digital, providing a fine adjusted cooperation of all elements.
    Digital Access Access Options