BookPramod C. Rath, editor.
Summary: The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.
Contents:
PART I ~ ALTERATIONS IN CELLULAR MECHANISMS DURING AGING
Chapter 1 Protein Structure and Function in Aging and Age-related Diseases
Chapter 2 DNA, DNA Replication and Aging
Chapter 3 Transcription and Aging
Chapter 4 Ribosomes, Translation and Aging
Chapter 5 p53 and Aging
Chapter 6 Paired Box (Pax) Transcription Factors and Aging
Chapter 7 Telomeres, Telomerase and Aging
Chapter 8 The Epigenome of Ageing
Chapter 9 Attaining Epigenetic Rejuvenation: Challenges Ahead
Chapter 10 Mitochondria as a Key Player in Aging
Chapter 11 Aging, Free Radicals and Reactive Oxygen Species: An Evolving Concept
Chapter 12 Stem Cells and Aging
Chapter 13 Can Autophagy Stop the Clock: Unravelling the Mystery in Dictyostelium discoideum
Chapter 14 Aging: Reading, Reasoning and Resolving Using Drosophila as a Model System
Chapter 15 Nothobranchius furzeri as a New Model System for Aging Studies
PART II ALTERATIONS IN METABOLISM DURING AGING AND DISEASES
Chapter 16 Aging in Muscle
Chapter 17 Metabolic Diseases and Aging
Chapter 18 Interplay Between Nutrient Sensing Molecules During Aging and Longevity
Chapter 19 Protein Aggregation, Related Pathologies and Aging
Chapter 20 Biological Rhythms and Aging
Chapter 21 The Biology of Ageing and Cancer
A Complex Association.