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  • Book
    Abdul W. Basit, Simon Gaisford, editors.
    Summary: 3D printing is forecast to revolutionise the pharmaceutical sector, changing the face of medicine development, manufacture and use. Potential applications range from pre-clinical drug development and dosage form design through to the fabrication of functionalised implants and regenerative medicine. Within clinical pharmacy practice, printing technologies may finally lead to the concept of personalised medicines becoming a reality. This volume aims to be the definitive resource for anyone thinking of developing or using 3D printing technologies in the pharmaceutical sector, with a strong focus on the translation of printing technologies to a clinical setting. This text brings together leading experts to provide extensive information on an array of 3D printing techniques, reviewing the current printing technologies in the pharmaceutical manufacturing supply chain, in particular, highlighting the state-of-the-art applications in medicine and discussing modern drug product manufacture from a regulatory perspective. This book is a highly valuable resource for a range of demographics, including academic researchers and the pharmaceutical industry, providing a comprehensive inventory detailing the current and future applications of 3D printing in pharmaceuticals. Professor Abdul Basit is a Professor of Pharmaceutics at the UCL School of Pharmacy, University College London. Abdul's research sits at the interface between pharmaceutical science and gastroenterology, forging links between basic science and clinical outcomes. His research has been translated into the design of new technologies and improved disease treatments, many of which have been commercialised. Abdul is also a serial entrepreneur and has filed multiple patents, is the recepient of several research awards and has founded 3 companies (Kuecept, Intract Pharma, FabRx). He further serves as a consultant to many pharmaceutical organisations and is on the advisory boards of scientific journals, healthcare and charitable bodies. Professor Simon Gaisford holds a Chair in Pharmaceutics and is Head of the Department of Pharmaceutics at the UCL School of Pharmacy, University College London. He has published 110 papers, 8 book chapters, 4 authored books and is the recipient of multiple research awards. His research is focused on novel technologies for manufacturing medicines, particularly using ink-jet printing and 3D printing, translating his expertise by co-founding FabRx. Simon is also an expert in the physicochemical characterisation of compounds and formulations with thermal methods and calorimetry.

    Contents:
    Intro; Preface; Contents; Contributors; About the Editors;
    Chapter 1: The Shape ofThings toCome: Emerging Applications of3D Printing inHealthcare; 1 3D Printing: TheNext Industrial Revolution; 1.1 3D Printing inMedicine: AnOverview; 2 Personalised Medicines; 2.1 Dose Personalisation; 2.2 Multi-drug Combinations; 2.3 Tailored Release Profiles; 2.4 Improved Patient Acceptability; 2.5 On-demand Printing; 3 Early Phase Drug Development; 3.1 Pre-clinical Studies andFIH Trials; 3.2 Motivations forUsing 3DP inEarly Phase Drug Development; 3.2.1 Dose Flexibility; 3.3 Immediate Manufacture 3.4 Reduced Resource Investment3.5 Unique Characteristics; 4 Conclusion; References;
    Chapter 2: 3D Printing Technologies, Implementation andRegulation: AnOverview; 1 Introduction; 2 Classification of3D Printing Technologies; 2.1 Industrial Applications of3D Printing; 2.2 3D Printing Software; 2.3 Binder JetPrinting; 2.4 Vat Polymerisation; 2.4.1 Stereolithography; 2.5 Powder Bed Fusion; 2.5.1 Selective Laser Sintering; 2.6 Material Extrusion; 2.6.1 Fused Deposition Modelling; 2.6.2 Semisolid Extrusion; 2.6.3 Bioprinting; 2.7 Directed Energy Deposition; 2.8 Sheet Lamination 3 3D Printing Implementation inHealthcare3.1 Rapid Administration andImproved Medicine Access; 3.2 3D Printing andWearable Diagnostics; 3.3 Challenges to3D Printing Implementation; 4 Regulatory Requirements; 4.1 Regulatory Considerations of3D Printing inPharmaceutics; 5 Conclusion; References;
    Chapter 3: Binder Jet Printing inPharmaceutical Manufacturing; 1 Introduction; 2 Binder Jet Methodology; 3 Pharmaceutical Applications ofBinder Jet Printing; 3.1 Controlled-Release Formulations; 3.2 Rapidly Dissolving Tablets; 3.3 SpritamĀ®: TheFirst FDA Approved 3D printed Product 4 Benefits andDrawbacks5 Conclusion; References;
    Chapter 4: The History, Developments andOpportunitiesofStereolithography; 1 Introduction; 1.1 History ofstereolithography; 2 Stereolithography; 2.1 The Stereolithographic 3DP Process; 2.2 Photopolymerisation; 2.2.1 Light Sources; 2.2.2 Photoinitiators; 3 Materials andBiomedical uses ofSterolithography; 3.1 Biocompatibility; 4 Conclusion; References;
    Chapter 5: Powder Bed Fusion: TheWorking Process, Current Applications andOpportunities; 1 Historical Development; 2 The Working Process; 2.1 Printing Parameters 2.1.1 Powder Bed Temperature2.1.2 Types ofLasers; 2.1.3 Particle Size andShape; 2.1.4 Layer Thickness; 2.1.5 Additional Parameters; 3 Classification; 3.1 Solid-State Sintering; 3.2 Liquid-Phase Sintering; 3.3 Partial Melting; 3.4 Liquid-State Melting; 4 Materials inPBF; 4.1 Thermoplastic Polymers; 4.2 Metals; 4.3 Ceramics; 5 Industrial Applications ofPBF; 5.1 Medical Applications ofPBF; 5.2 Metallic Devices; 5.3 Tissue Engineering; 5.4 PBF inPharmaceutics; 6 Conclusion; References;
    Chapter 6: Fused Deposition Modelling: Advances inEngineering andMedicine; 1 Introduction
    Digital Access Springer 2018