BookIqbal Ahmad, Shamim Ahmad, Kendra P. Rumbaugh, editors.
Summary: This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.
Contents:
Antibacterial drug discovery: perspective insights
Section A: The Challenge of Antibiotic Resistance and Tolerance
Problematic Groups of Multidrug Resistant Bacteria and their Resistance Mechanisms
Emergence and spread of multi-drug resistance in ocular bacterial pathogens: A current update
Antibiotic resistance in Campylobacter jejuni: mechanism, status and public health significance
Mechanisms of biofilm development, antibiotic resistance & tolerance and their role in persistent infections
Developing in vivo infection models with MDR pathogens for evaluating compound efficacy
Section B. New antibiotic drug discovery approaches and progress
Endophytes: a hidden treasure of novel antimicrobial metabolites
Alternative therapies to antibiotics to combat drug-resistant bacterial pathogens
In silico molecular modeling: key technologies in the drug discovery process to combat multidrug resistance
Computational approaches for antibacterial drug discovery
Efflux pump inhibitors and their role in the reversal of drug resistance
Medicinal plants as a reservoir of new structures for anti-infective compounds
Essential oils: Potential application in disease management
Exploration of soil resistome through a metagenomic approach
Actinomycetes as a continued source of new antibacterial leads
Are Ancient Remedies the New Answer to Fighting Infections?
Section C. Alternative antibiotic resistance treatment strategies
Pre and probiotics: Using functional foods in the fight against microbial resistance to antibiotics
Combination of drugs: an effective approach for enhancing the efficacy of antibiotics to combat drug resistance
Targeted delivery of antibiotics using microparticles to combat multi-drug-resistant tuberculosis
Practical applications of bacteriophage therapy: biofilms to bedside
Inhibition of Quorum sensing; prospects in disease control
Approaches for disrupting tissue-associated biofilms
Nanomedic ine and nanoemulsion in increasing the availability of antibiotics
Nanoparticles as new emerging antibacterials: potential and limitation
Nanomaterials as a novel class of anti-infective agents that attenuate bacterial quorum sensing
Nanoparticle-based drug delivery systems: promising approaches against bacterial infections
Green synthesis of metal nanoparticles: characterization and their antibacterial efficacy.