BookSajal Chakraborti, Naranjan S. Dhalla, Madhu Dikshit, Nirmal K. Ganguly, editors.
Summary: This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Contents:
A. Regulation of Oxidative Stress
1. Impact of genetic and epigenetic factors on the oxidative stress in cardiovascular disease
2. Role of aging and metabolic disease in oxidative stress of heart
3. Role of monoamine oxidases in heart diseases
4. Role of miRNA in oxidative stress induced heart diseases
5. Modulation of Oxidative (stressed) Heart Disease by Uncoupling Proteins
6. Redox regulation in heart by ion channels
7. Molecular regulators in ROS mediated cardiac diseases.
8. The inflammatory stress that follows preceded oxidative stresses in the pathogenesisof heart diseases
9. Metabolic signatures of redox-dependent cardiovascular disease.
10. Role of heat shock proteins in oxidative stress induced heart diseases. B. Pathophysiology of Oxidative Stress
11. Oxidative stress in metabolic syndrome : experimental model of biomarkers
12. Oxidative stress as a critical determinant of adult cardiac progenitor cell-fatedecisions
13. Role of oxidative stress in hyperhomocysteinemia-induced heart disease
14. Oxidative Stress and the Aging Heart
15. Basic mechanisms of ischemia/reperfusion injury leading to cellular and tissuedamage
16. Oxidative stress in congenital heart defects.
17. Nitrosative stress and cardiogenesis: Cardiac remodeling perturbs embryonicmetabolome
18. Oxidative Stress and Mitochondrial Dysfunction in Heart Diseases
19. Role of oxidative stress, mitochondrial dysfunction and autophagy in cardiovasculardisease: Its pathogenesis and amelioration by different small natural molecules
20. Regulation of cardiac ion channels in stress related heart diseases 21.In silico perspectives of the mechanism of oxidative stress during the onset of heart disease. 22.Biomarkers of oxidative stress and endothelial dysfunction in the elderly: oxidizedLDL versus LDL oxidizability C. Prevention & therapeutics
23. Restoring nitroso-redox balance as a therapeutic for heart disease
24. Oxidative stress role in cardiovascular prevention and disease
25. Mitochondrial dynamics and mitophagy in heart: role in disease and interventional opportunities
26. Role of exercise in prevention and treatment of heart diseases: focus on redox balance
27. Mitochondrial biology and its therapeutic use in cardiovascular disease
28. Oxidative stress-driven cardiotoxicity of cancer drugs.
29. Modifying redox signaling to enhance success of regenerative therapy in the heart.