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  • Book
    Andrzej Górski, Ryszard Miȩdzybrodzki, Jan Borysowski, editors.
    Summary: This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies.

    Contents:
    Part I: Bacteriophages as antibacterialagents
    Chapter 1:Production of PhageTherapeutics and Formulations
    InnovativeApproaches
    Chapter 2:Phagepharmacokinetics: relationship with administrationroute
    Chapter 3:BacterialResistance to Phage and itsImpact on Clinical Therapy
    Part II: Bacteriophages and the immune system
    Chapter 4:Phageinteraction with the mammalianimmune system
    Chapter 5:Humoralimmuneresponse to phage-basedtherapeutics
    Part III:Use of bacteriophages to combat bacterial infections
    Chapter 6:How to achieve a goodphage therapy clinical trial?
    Chapter 7: Perspectives on the RenewedInterest in the United States
    Chapter 8:Phage Therapy in Orthopaedic Implant-associated Infections
    Chapter 9:The use of bacteriophages in animalhealth and food protection
    Chapter 10:Combiningbacteriophages with otherantibacterialagents to combatbacteria
    Chapter 11: Phage therapy of infectious biofilms: Challenges and strategies
    Part IV:Phage therapy
    regulatory and ethical aspects
    Chapter 12:Regulatory Considerations for Bacteriophage Therapy Products
    Chapter 13:Developing phagesintomedicines for Europe
    Chapter 14: Phagetherapy in Europe: Regulatory and intellectualpropertyprotectionissues
    Chapter 15:Ethics of phagetherapy
    Part V: Bacteriophage-derived antibacterial agents
    Chapter 16: NovelAlternative to Antibiotics.
    Digital Access Springer 2019
  • Article
    Dutcher BS, Reynard AM, Beck ME, Cunningham RK.
    Antimicrob Agents Chemother. 1978 May;13(5):820-6.
    Combinations of certain antibiotics and normal human serum at concentrations at which there was no killing by the agents when used alone were found to be bactericidal for Escherichia coli K-12 cells. This effect was observed with tetracycline, streptomycin (SM), trimethoprim, and ampicillin, but not with chloramphenicol or nalidixic acid. Synergy between SM and human serum was also observed against four of nine smooth strains of E. coli. A plasmid-bearing strain of E. coli K-12 was also killed by combinations of tetracycline or SM plus serum, even though the plasmid conferred resistance to tetracycline and SM. Evidence is presented that the synergy between antibiotics and serum is due to a complement-mediated effect on the bacterial cells that makes the cells more susceptible to the bactericidal effects of the antibiotics.
    Digital Access Access Options
  • Journal
    Print Began publication in 1925; suspended 1939-44, 1948-53.