Search
Filter Results
- Resource Type
- Article1
- Book1
- Book Digital1
- Journal1
- Result From
- Lane Catalog1
- PubMed1
- SearchWorks (biomedical subset) 1
-
Year
- Journal Title
- Antimicrob Agents Chemother1
Search Results
Sort by
- BookMalali Gowda, Ambardar Sheetal, Chittaranjan Kole, editors.Summary: This book describes the sequencing efforts for Neem (Azadirachta indica A. Juss), one of the most versatile tropical evergreen tree species. The neem tree is a source of various natural products, including the potent biopesticide azadirachtin and limonoids, which have a broad spectrum of activity against insect pests and microbial pathogens. To identify genes and pathways in neem, three neem genomes and several transcriptomes are studied using next-generation sequencing technologies. Neem has been extensively used in Ayurveda, Unani and homoeopathic medicine and is often referred to as the 'village pharmacy by natives due to its wealth of medicinal properties. Besides the description of the genome, this book discusses the neem microbiome and its role in the production of neem metabolites like salanin, nimbin and exopy-azadirachtin under in vitro conditions. It also highlights cell and tissue culture using various neem explants including the leaf, root, shoot, cambium, etc.
Contents:
Economic/Academic importance
Botanical descriptions and distribution
Traditional practices and knowledge of neem
Biochemistry, medicinal properties and molecular biology of neem bioactives
Quantification of secondary metabolites of neem
Utilization of neem and neem products in agriculture
Requirement of whole-genome sequencing
Strategies & tools for sequencing
Genome Assembly
Repetitive sequences
Gene annotation
Synteny with allied & model genomes
Comparison of gene families
Impact on neem tree improvement breeding
Neem tissue culture
Neem microbiome
Future prospects. - ArticleLaverdiere M, Welter D, Sabath LD.Antimicrob Agents Chemother. 1978 Apr;13(4):669-75.The in vitro activity of 19 cephalosporins against 105 clinical isolates of Staphylococcus aureus and S. epidermidis was determined by using a heavy inoculum, i.e., 10(8) to 10(9) organisms per ml, to maximally challenge the antibiotics. The anti-staphylococcal activities of cephaloridine and 87/312 were consistently decreased by the use of a heavy inoculum when compared with the activity obtained with two less-concentrated inocula. The activity of most of the other compounds was also decreased with the use of a heavy inoculum, but this was observed only with selected isolates. Cephapirin, cephalothin, and cefazaflur were the most active drugs against the methicillin-susceptible isolates. Cephaloridine, cefamandole, cefazaflur, and 87/312 had substantial activity against methicillin-resistant staphylococci even with heavy inocula. With the exception of cefaclor against S. aureus, the orally absorbed cephalosporins were generally one-half to one-sixteenth as active as the parenterally administered cephalosporins. The median minimal inhibitory concentrations of five of the 12 parenteral cephalosporins were lower with the methicillin-susceptible S. aureus than with the methicillin-susceptible S. epidermidis strains.