BookMasayuki Saijo, editor.
Summary: This book presents the latest knowledge on all aspects of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease endemic to China, South Korea, and Japan that is caused by a bunyavirus first discovered in 2011, widely referred to as SFTS virus (SFTSV) though recently renamed Huaiyangshan banyangvirus. The contents will be of interest for the light that they cast on not only this viral infection but viral hemorrhagic fevers in general. The opening chapters summarize general considerations and perspectives regarding SFTS and describe the discovery process in each of the affected countries. The basic mechanism of SFTSV infection is then examined from the perspectives of epidemiology, pathology, and virology. The book goes on to examine in detail the mode of spread and transmission of SFTSV, means of infection control, and diagnosis and therapy. The final two chapters explore Heartland virus infections and Crimean-Congo hemorrhagic fever with the aim of highlighting similarities and differences compared with SFTS. This book will be of interest to all researchers who study emerging viruses and infections, whether in Asia or elsewhere, as well as to clinicians who may encounter SFTS.
Contents:
Intro; Preface; Contents;
Chapter 1: Introduction; 1.1 Introduction; 1.2 Discovery of a Novel Viral Hemorrhagic Fever-like Infection, SFTS, in Peoples' Republic of China; 1.3 Discovery of SFTS Epidemics in Japan and South Korea; 1.4 Causative Virus, SFTSV; 1.5 Similarity and Difference in the Characteristics Between Two Bunyavirus Infections SFTS and CCHF; 1.6 Life Cycle of SFTSV and the Transmission Route of SFTSV to Humans; 1.7 Epidemiology; 1.8 Clinical Manifestations; 1.9 Laboratory Diagnosis; 1.10 Pathology and Pathophysiology; 1.11 Necessity to Develop Specific Treatment for SFTS 1.12 Necessity to Develop Specific Preventive Measures against SFTS1.13 Conclusion; References;
Chapter 2: The Discovery Process of SFTS in China; 2.1 Introduction; 2.2 Case Surveillance; 2.3 Identification of the Viral Gene and Genetic Analysis; 2.4 Isolation of the Novel Virus; 2.5 Detection of the Virus in the Patients with SFTS; 2.6 Conclusion; References;
Chapter 3: The Discovery Process of SFTS in Japan; 3.1 Introduction; 3.2 The First Patient Diagnosed with SFTS in Japan; 3.2.1 Case Presentation (Takahashi et al. 2014); 3.2.2 Definitively Diagnosing the Patient (Takahashi et al. 2014) 3.2.3 Public Announcement of the First Patient with SFTS in Japan (Saito et al. 2015)3.2.4 The First Retrospective Study for SFTS in Japan (Takahashi et al. 2014); 3.3 Intuitional Cooperation; 3.4 Conclusion; References;
Chapter 4: Severe Fever with Thrombocytopenia Syndrome in the Republic of Korea; 4.1 Detection of the First SFTS Case in the Republic of Korea; 4.1.1 Case Description; 4.1.2 Isolation of SFTS Virus from the First Case (Kim et al. 2013); 4.1.3 Characterization of the Isolate of SFTS Virus; 4.2 Epidemiology of SFTS in Human 4.3 Phylogenetic Analysis of SFTS Virus Isolated from the Republic of Korea4.4 Future Direction; References;
Chapter 5: Virology of SFTSV; 5.1 Genomic Structure of SFTSV; 5.2 Structural Proteins; 5.2.1 N protein; 5.2.2 GP Precursor, Gn, and Gc; 5.2.3 L Protein; 5.3 Nonstructural Protein; 5.4 Assembly of Virus Particles; 5.5 Plaque Formation and Cytopathic Effect in SFTSV-Infected Cells; 5.6 Syncytium Formation of SFTSV-Infected Cells Induced by pH-Dependent Membrane Fusion; 5.7 Transportation of Viral Proteins in Cells; References;
Chapter 6: Molecular Epidemiology of SFTSV; 6.1 Introduction 6.2 The Impact of in vitro Passaging on the Nucleotide Sequences of SFTSV Genomes6.3 Phylogenetic Analysis; 6.4 The Nucleotide and Amino Acid Sequence Homology Between SFTSV Strains; 6.5 The Geographical Distribution of SFTSV Strains; 6.6 The Migration of the SFTSV Strains Beyond the Geographical Separation; References;
Chapter 7: Epidemiology of SFTS in China; 7.1 Introduction; 7.2 Surveillance System in China; 7.3 Case Definition of SFTS; 7.4 Disease and Geographical Distribution; 7.5 Geographical Distribution; 7.5.1 Henan Province; 7.5.2 Shandong Province; 7.5.3 Hubei Province