BookJin-Hui Wang.
Summary: This book focuses on associative memory cells and their working principles, which can be applied to associative memories and memory-relevant cognitions. Providing comprehensive diagrams, it presents the author's personal perspectives on pathology and therapeutic strategies for memory deficits in patients suffering from neurological diseases and psychiatric disorders. Associative learning is a common approach to acquire multiple associated signals, including knowledge, experiences and skills from natural environments or social interaction. The identification of the cellular and molecular mechanisms underlying associative memory is important in furthering our understanding of the principles of memory formation and memory-relevant behaviors as well as in developing therapeutic strategies that enhance memory capacity in healthy individuals and improve memory deficit in patients suffering from neurological disease and psychiatric disorders. Although a series of hypotheses about neural substrates for associative memory has been proposed, numerous questions still need to be addressed, especially the basic units and their working principle in engrams and circuits specific for various memory patterns. This book summarizes the developments concerning associative memory cells reported in current and past literature, providing a valuable overview of the field for neuroscientists, psychologists and students.
Contents:
Intro; Preface; Acknowledgement; Contents; About the Author;
Chapter 1: History in the Study of Learning and Memory; 1.1 Introduction; 1.2 Memory Traces; 1.3 Engrams; 1.4 The Location and Distribution of Memory Traces or Engrams; 1.5 The Identification of Basic Units in Engrams: Memory-Relevant Cells; 1.6 Biophysical Changes in Memory-Relevant Cells: Neuronal and Synaptic Plasticity; 1.7 Memory-Specific Activity Patterns as Basic Units of Memory Traces; 1.8 The Recruitment of Memory-Relevant Neurons by Their Coactivation: Associative Memory Cells 1.9 Major Milestones in the Study of Mechanisms Underlying Learning and Memory1.9.1 Theoretical Modeling; 1.9.2 Animal Model; 1.9.3 Location and Distributions; 1.9.4 Cellular Architectures in Engram Circuits; 1.9.5 Molecular Mechanisms; References;
Chapter 2: Patterns of Learning and Memory; 2.1 Introduction; 2.2 Associative Learning and Nonassociative Learning; 2.3 Declarative (Explicit) Memory Versus Nondeclarative (Implicit) Memory; 2.3.1 Declarative Memory; 2.3.2 Nondeclarative Memory; 2.4 Episodic Memory Versus Semantic Memory; 2.4.1 Episodic Memory; 2.4.2 Semantic Memory 2.5 Working Memory and Perceptual Memory2.5.1 Working Memory; 2.5.2 Perceptual Memory; 2.6 Eidetic Memory and False Memory; 2.6.1 Eidetic Memory; 2.6.2 False Memory; 2.7 Other Types of Memory; 2.8 Learning and Memory in Relevance to Ages; References;
Chapter 3: Experimental Models and Strategies for Studying Associative Learning and Memory; 3.1 Introduction; 3.2 Experimental Models Used to Track Engrams; 3.2.1 Classical Conditioning; 3.2.2 Operant Conditioning; 3.2.3 Spatial Learning and Memory; 3.2.4 Associative Learning and Memory in Reciprocal Manner 3.3 Strategies Used to Track Memory Cells in Engrams3.3.1 Theoretical Modeling from Memory Traces to Cell Assemblies; 3.3.2 Parallel Changes Between Engrams and Memory-Relevant Behaviors; 3.3.3 Downregulation of Neural Substrates; 3.3.4 Upregulation of Neural Substrates; References;
Chapter 4: Cellular and Molecular Changes in Associative Memory; 4.1 Introduction; 4.2 Synapses, Neurons, and Their Functional Changes; 4.3 Synaptic Plasticity; 4.3.1 Synaptic Facilitation; 4.3.2 Long-Term Potentiation of Synaptic Transmission; 4.4 Neuronal Plasticity; References
Chapter 5: Associative Memory Cells in Memory Trace5.1 Introduction; 5.2 Associative Memory Cells in Theory and Experiments; 5.3 Associative Memory Cells in Sensory Cortices; 5.4 Associative Memory Cells in Cognition- and Emotion-Related Brain Areas; 5.5 Memory Output Cells in Behavior-Related Brain Areas; References;
Chapter 6: Plasticity of Associative Memory Cells; 6.1 Introduction; 6.2 Plasticity at Primary Associative Memory Cells Linked with Their Recruitment; 6.3 Plasticity at Secondary Associative Memory Cells; 6.4 Plasticity at Memory Output Cells