BookSajal Chakraborti [and three others], editors.
Summary: This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.
Contents:
Intro; Preface; Contents; Editors and Contributors; Part I: General Implications of Oxidative Stress on Lungs;
1: Nutrition in Inflammatory Lung Diseases; 1.1 Introduction; 1.2 Oxidative Stress; 1.2.1 Free Radicals; 1.2.2 Oxygen Reactive Species; 1.2.3 Oxidative Stress; 1.2.3.1 Implications of Oxidative Stress in the Organism; 1.2.3.2 Oxidative Damage in Lung; 1.3 Inflammation in Lung Diseases; 1.3.1 Inflammatory Cellular Response; 1.3.2 Biological Barriers in Lung; 1.3.3 Acute and Chronic Lung Inflammation; 1.4 Interaction of Nutrients with Inflammatory Elements 1.5 Role of the Diet in Lung Diseases1.5.1 Mediterranean Diet; 1.5.2 Western Diet; 1.5.3 Fruit and Vegetable Consumption; 1.6 Conclusion; References;
2: Oxidative Stress and Smoke-Related Lung Diseases: A Tentative Approach Through the Blood, Lungs, and Gut; 2.1 Introduction; 2.2 Exogenous and Endogenous Oxidation; 2.3 Regeneration of Lung Cells; 2.4 Oxidative Stress in the Lungs; 2.5 Oxidative Stress Markers; 2.6 Antioxidant Defense System; 2.7 Lung Pathology and Oxidative Stress; 2.7.1 COPD; 2.7.2 Bronchial Asthma; 2.7.3 Idiopathic Pulmonary Fibrosis; 2.7.4 Lung Cancer 2.8 Lung Disease Statistics2.9 Molecular Mechanism of Lung Diseases; 2.10 Impact of Smoking on Lung Diseases; 2.11 Lung Disease and Gut Ecosystem; 2.12 Rational Basis for a Systemic Antioxidant and Parenteral/Transmucosal Oxygen-Ozone Tentative Interventional Trial: The Cell-Energy Modulation Biotech, CMB® Protocol; 2.13 Using Natural Antioxidants and Nutrigenomic Cytoprotective Agents to Prevent Oxidative Stress Damage in Lung Caused by Cigarette Smoking; 2.14 Conclusion and Future Direction; References;
3: Oxidative Stress in Neonatal Lung Diseases; 3.1 Introduction 3.2 Perinatal Transition3.3 Vasoactive Molecules Are Involved in the Perinatal Transition; 3.3.1 Nitric Oxide (NO); 3.3.2 Prostacyclin (PGI2); 3.3.3 Thromboxane A2 (TXA2); 3.3.4 Endothelin; 3.4 Free Radical Generating Systems; 3.4.1 Mitochondrial Electron Transport Chain; 3.4.2 NADPH Oxidase (NOX); 3.4.3 eNOS Uncoupling; 3.5 Free Radicals in Neonates; 3.6 Antioxidant System; 3.6.1 General Aspects; 3.6.2 Caffeine; 3.6.3 Melatonin; 3.6.4 Taurine; 3.7 Neonatal Lung Diseases; 3.7.1 General Aspects; 3.7.2 Respiratory Distress Syndrome (RDS) and Bronchopulmonary Dysplasia (BPD) 3.7.3 Persistent Pulmonary Hypertension of the Newborn (PPHN)3.8 Conclusion; References;
4: DNA Repair Protein OGG1 in Pulmonary Infection and Other Inflammatory Lung Diseases; 4.1 Introduction; 4.2 DNA Repair Protein OGG1 Response to Lung Infection; 4.2.1 OGG1 Plays a Role in Bacterial Infection; 4.2.1.1 Pseudomonas aeruginosa; 4.2.1.2 Klebsiella pneumoniae; 4.2.1.3 Other Bacteria; 4.2.2 OGG1 Affects Viral Infection; 4.2.3 OGG1 Affects Fungus Infection; 4.3 OGG1 Is Linked to Inflammatory Lung Diseases; 4.3.1 OGG1 Responses in Pulmonary Hyperoxia