BookHiroshi Mitoma, Mario Manto, editors.
Summary: A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases.
Contents:
Intro; Contents; Part I: Fundamental Mechanisms and General Principles; Overview of Mechanisms Underlying Neuroimmune Diseases; Introduction; Divergence and Convergence in Neuroimmune Diseases; Blood-Brain Barrier and Blood-Nerve Barrier; Local Immune Cascades; Therapeutic Strategies of Neuroimmune Diseases; Clinical Features of Neuroimmune Diseases; Lesion-Dependent Neurological Symptoms; Association of Other Neuroimmune Diseases; Multifocal Lesions; Divergent Immune Mechanisms; Fundamental Pathogenic Factors Determining Clinical Profiles; Autoantibody- and Cell-Mediated Immune Mechanisms Actions of Divergent Pro-Inflammatory CytokinesTh17 Cell Plasticity; Multiple Actions of IL-17; Th17-Related Inflammation and the Neuronal Apoptosis; Multiple Actions of IL-22, IL-23, and GM-CSF; Open Problems and Therapeutic Applications; The Role of Th17 Cells in Immunopathogenesis of Alzheimer Disease; Link Between Immune System and Neurodegeneration; Th17-Mediated Mechanisms in Alzheimer Disease; The Role of Th17 Cells in Immunopathogenesis of Parkinson Disease; Immune-Mediated Mechanisms in Parkinson Disease; Th17 Cell Role in Parkinson Disease Neuroimmune Mechanisms in Neuropsychiatric DiseasesFuture Perspective; References; Roles of Effector T Cells in Neurological Autoimmunity; Introduction; Dysregulation of the Th1/Th2 Balance in MS; Th17 Cells in MS/EAE; CD8 T Cells in MS/EAE; Possible Therapeutic Targets for Neurodegeneration and Demyelination in MS and EAE; Conclusion; References; The Role of Th17 Cells in Immunopathogenesis of Neuroinflammatory Disorders; Introduction; The Role of Th17 Cells in Immunopathogenesis of Multiple Sclerosis; Roles of Th1 and Th17 Cells in Pathogenesis of Multiple Sclerosis Neuroinflammatory CascadesTriggering of Autoimmunity: Parainfectious and Paraneoplastic Conditions; Cross Talk Between the Immune System and Degenerative or Psychiatric Diseases; Mechanisms of Neuroimmune Diseases; Mechanisms of T Cell-Mediated Neuroinflammation and Autoimmunity; Mechanisms of Antibody-Mediated Neuroinflammation and Autoimmunity; Role of Infections in the Neuroinflammation and Autoimmunity; Neuroimmune Mechanisms in Paraneoplastic Diseases; Neuroimmune Mechanisms in Vascular Inflammatory Diseases; Neuroimmune Mechanisms in Neurodegenerative Diseases The Role of Th17 Cells in Immunopathogenesis of Schizophrenia DiseaseImmunopathology of Schizophrenia Disease; Immunopathology of Schizophrenia from Th17 Cell Viewpoint; Conclusion; References; Significance of Autoantibodies; Introduction; Theme A: Causes of Antibody Development; Paraneoplastic Neurologic Disorders (PNS); Clinical Example; Anti-Yo Antibody-Associated Paraneoplastic Cerebellar Degenerations; Infection; Clinical Example; Herpes Simplex Virus-1 (HSV-1) Encephalitis and NMDAR Encephalitis; Injuries to the CNS; Clinical Example