BookDelphine J. Lee, Mark B. Faries, editors.
Summary: This book provides a practically applicable resource for all clinicians managing patients with or who may develop melanoma. Each chapter focuses on clinically relevant information on the latest advances in the field, including techniques for early detection of skin cancers, cross-sectional imaging and staging of regional nodes. Algorithms for clinical decision-making along with clinical vignettes are incorporated into each chapter, enabling the reader to develop a deep understanding of how to manage a range of scenarios. Practical Manual for Dermatologic and Surgical Melanoma Management systematically details the latest diagnostic criteria, treatment guidelines and management techniques available for treating these patients and is a valuable resource for the trainee and practising clinician.
Contents:
Intro
Contents
Chapter 1: Can We End Melanoma As We Know It? The Role of Early Detection in Defeating Deadly Skin Cancer
Introduction
Case
Additional Clinical History
Melanoma Risk Factors
Physical Exam Findings
Discussion
Critical Take Home Messages
References
Chapter 2: Melanoma Risk Factors and Prevention
Introduction
Case
Melanoma Disparities
Risk Factors
Phenotypic Features
Personal Medical History
Genetic Predisposition/Family History
Environmental Factors
Screening
Prevention
Discussion of Case
Conclusions Mutational Load
Sentinel Lymph Nodes (SLN)
Discussion of Case
Conclusions
References
Chapter 4: Melanoma Epidemiology, Staging and Prognostic Factors
Introduction
Melanoma Epidemiology
Melanoma Staging
Prognostic Factors in Melanoma
Depth of Invasion
Ulceration
Mitotic Rate
Growth Phase and Melanoma Subtypes
Regression
Tumor Infiltrating Lymphocytes
Lymphatic Invasion and Angiotropism
Neurotropism
Nevus Association
Age
Gender
Marital Status
Anatomical Location
Tumor Derived Markers
Molecular Markers of Melanoma Prognosis Conditional Survival
Summary
References
Chapter 5: Imaging in Melanoma
Lymphoscintigraphy for Sentinel Node Biopsy
Lymphoscintigraphy Technique
Possible Radiation Risk of LS
Potential Problems with LS
Wide Local Excision (WLE)
Reproducibility
The Melanoma Site Immediately Overlies a Node Field
Conclusion
Ultrasound in Melanoma Patients
Diagnosis
Patient Case
Does US Have a Role in Primary Assessment of Melanoma?
Staging
Case Continued
What Are the US Criteria for Defining Normal and Abnormal Lymph Nodes? What Is the Role of US Assessment of the Regional Lymph Node Basins Before Sentinel Node Mapping and/or Biopsy?
Follow Up
Case Continued
How Is US Used in Follow Up?
Conclusion
Cross Sectional Imaging
Staging
Early Stage Disease
Later Stage Disease
Monitoring the Effects of Therapy
Post Treatment Surveillance
Effect on Survival
Conclusion
References
Chapter 6: Primary Melanoma Treatment
Case
Introduction
Operative Primary Melanoma Treatment
Wide Excision
Technique
Recommended Margins for Wide Excision
Clinical vs Pathologic Margins