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  • Journal
    Pub. under the auspices of the Johns Hopkins University.
    Digital Access v. 1- ; 1878-
  • Book
    Shailza Singh, editor.
    Summary: The book uses an integrated approach to predict the behavior of various biological interactions. It further discusses how synthetic biology gathers the information about various systems, in order to either devise an entirely new system, or, to modulate existing systems. The book also tackles the concept of modularity, where biological systems are visualized in terms of their parts. The chapters discuss how the principles of engineering are being used in biomedical sciences, to design biological circuits that can harbor multiple inputs and generate multiple outputs; to create genetic networks and control gene activity, in order to generate a desired response. The book aims to help the readers develop an array of biological parts, and to use these parts to develop synthetic circuits that can be assembled like electronic circuits. The ultimate aim of the book will be to serve as an amalgamation of key ideas of how judiciously synthetic biology could be exploited in therapeutic device and delivery mechanism.

    Contents:
    Chapter 1. Integrated Systems and Chemical biology approaches for targeted therapies
    Chapter 2. Application of bioengineering in revamping human health
    Chapter 3. Integrative Omics for Interactomes
    Chapter 4. Studying parasite gene function and interaction through ribozymes and riboswitches design mechanism
    Chapter 5. Genome microbiology for Synthetic applications
    Chapter 6. Medicinal Application of Synthetic Biology
    Chapter 7. Computational tools for applying multi-level models to Synthetic Biology
    Chapter 8. Computational techniques for a comprehensive understanding of different genotype-phenotype factors in biological systems and their applications
    Chapter 9. Alignment-free analyses of nucleic acid sequences using graphical representation
    Chapter 10. Modern Approaches in Synthetic Biology: Genome Editing, Quorum Sensing and Microbiome Engineering
    Chapter 11. Synthetic Probes, their applications & designing
    Chapter 12. Omics Based Nanomedicine
    Chapter 13. Characterization of plant genetic modifications using Next Generation Sequencing.
    Digital Access Springer 2018
  • Article
    Hollingdale MR, Herrmann JE, Vinson JW.
    J Infect Dis. 1978 May;137(5):578-82.
    Enzyme immunoassay (EIA) tests were used to diagnose trench fever and to determine cross-reactions of Rochalimaea quintana with other rickettsiae. The results were compared with those obtained by counterimmunoelectrophoresis (CIE). All sera from cases of primary or relapsed forms of trench fever were positive both in EIA, with serum antibody titers of 1:20-1:640, and in CIE, giving one to three precipitin lines. Sera from patients with other rickettsial infections were also tested for reactivity with R. quintana antigen: typhus group (Rickettsia prowazekii, Ricketsia mooseri), 15 sera; spotted fever group (Ricketsia ricketsii, Rickettsia akari), eight sera; and scrub typhus (Rickettsia tsutsugamushi), six sera. Strong reactions occurred with four sera from patients with scrub typhus, giving one or two lines in CIE and EIA titers of 1:40-1:160; these results were extended to guinea pig antisera to R. tsutsugamushi. About 50% of typhus group sera reacted with a single line in CIE and had antibody titers of 1:20-1:80 by EIA. The results show that EIA is accurate for the diagnosis of trench fever and, with the results obtained by CIE, suggest that R. quintana is antigenically related to R. tsutsugamushi and possibly to rickettsiae in the typhus group as well.
    Digital Access Access Options