BookRaul Delgado-Morales, editor.
Summary: This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer's disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.
Contents:
Part I: Stem cells for brain disorders
Chapter 1: Human induced pluripotent stem cell-derived neurons to model and gain insights into Alzheimer's disease pathogenesis
Chapter 2: Modeling schizophrenia with human stem cells
Chapter 3: Rett Syndrome and Stem Cell research
Chapter 4: Stem Cell Applications in Spinal Cord Injury: A Primer
Chapter 5: Cell-Based Therapy for Retinal Degenerative Disease
Chapter 6: Past, present and future of cell based-therapy in progressive multiple sclerosis
Part II: Stem cells for cardiovascular diseases
Chapter 7: Cardiac Stem Cells: a plethora of potential therapies for myocardial regeneration within reach
Chapter 8: Human Induced Pluripotent Stem Cell-derived Cardiomyocytes in the Evaluation of Cardiotoxic Potential of Drugs
Part III: Stem cells for general medicine
Chapter 9: Regenerative medicine for diabetes treatment: new cell sources
Chapter 10: Dental pulp stem cells promote wound healing and muscle regeneration
Chapter 11: From bench to bedside of mesenchymal Stem Cells use for Rheumatoid Arthritis treatment
Chapter 12: Stem Cells and Cancer
Chapter 13: The relevance of induced pluripotent stem cells for the study of physiological and premature aging
Part IV: Technical challenges and future
Chapter 14: Pluripotent stem cell banks
Chapter 15: Genetic and Epigenetic engineering: the CRISPR/Cas9 era.