BookPandjassarame Kangueane, Christina Nilofer.
Summary: This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.
Contents:
1. Introduction
2. Protein-protein binding
3. Low-resolution protein complexes
4. Heterodimer protein complexes
5. Homo multimer protein complexes
6. Hetero multimer protein complexes
7. Hot spots at the protein-protein interface
8. Principles of protein-protein interaction
Databases for protein-protein interaction
10. Homodimer protein folding and binding
11. Protein subunit-subunit to domain-domain interactions
12. Domain-domain interactions
13. Protein-protein interaction tools
14. Protein-protein docking: Methods and tools
15. HLA-peptide interaction to short peptide vaccine design
16. Protein-protein interfaces and diseases
17. Patented protein structural complexes in discovery platform
18. Proteome-scale analysis of protein complexes
19. Conclusions and challenges
Useful formula.