BookRosa Barrio, James D. Sutherland, Manuel S. Rodriguez, editors.
Summary: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Contents:
Intro
Preface
Acknowledgments
Contents
Part I: Cancer
Chapter 1: Ubiquitin-Regulated Cell Proliferation and Cancer
1.1 Introduction to Cell Cycle Regulation
1.1.1 Regulation of CDK-Cyclin Activity by the UPS
1.1.2 SCF in Cell Cycle Control
1.1.3 SCF in DNA Damage
1.1.4 APC/C and the Regulation of Mitosis
1.2 Non-proteolytic Protein Ubiquitination in the Control of Cell Cycle Progression
1.2.1 Cell Signaling and Non-proteolytic Protein Ubiquitination in G1
1.2.2 Non-proteolytic Protein Ubiquitination During G1/S to G2 Transition 2.4.1.1 Ubiquitin E1 Inhibitors
2.4.1.2 Nedd8 E1 Inhibitors
2.4.1.3 SUMO E1 Inhibitors
2.4.2 E2 Inhibitors
2.4.3 E3 Inhibitors
2.4.3.1 MDM2 Inhibitors
2.4.3.2 IAP Inhibitors
2.5 Conclusion
References
Chapter 3: The Proteasome System in Health and Disease
3.1 Introduction
3.2 20S Proteasomes: Structure and Regulation
3.2.1 Alternative Composition of the 20S Proteasome
3.2.2 Expression and Assembly of the 20S Proteasome
3.2.3 Activation of the 20S Proteasome
3.2.4 Posttranslational Modifications (PTMs)
3.2.5 Localization 3.4 Proteasomes in Diseased States