Bookedited by Benjamin Z. Leder, Marc N. Wein.
Summary: Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care. In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.
Contents:
Basic Aspects of Osteoblast Function
Basic Aspects of Osteoclast Differentiation and Function
Basic Aspects of Osteocyte Function
Vitamin D and Bone Health: Basic and Clinical Aspects
Basic Aspects of Bone Mineralization
Determinants of Peak Bone Mass Acquisition
Osteoporosis Screening and Diagnosis
New Imaging Techniques for Bone
Biochemical Markers of Bone Turnover
Biomechanics of Bone
Exercise in the Prevention of Osteoporosis-Related Fractures
Effects of Estrogens and SERMs on Bone Metabolism: Clinical Aspects
The Effects of Androgens on Bone Metabolism: Clinical Aspects
Bisphosphonates: Mechanisms of Action and Role in Osteoporosis Therapy
Denosumab: Mechanisms and Therapeutic Effects in the Treatment of Osteoporosis
The Parathyroid Hormone Receptor Type 1
PTH and PTHrP Analogs: Treatment of Osteoporosis
Combination and Sequential Osteoanabolic/Antiresorptive Therapy in Osteoporosis Treatment
Sclerostin Inhibition in the treatment of Osteoporosis
Osteoporosis in Men. Glucocorticoid-Induced Osteoporosis
Transplantation Osteoporosis
Osteoporosis in Premenopausal Women
Safety Considerations for Osteoporosis Therapies
Genetic Determinants and Pharmacogenetics of Osteoporosis and Osteoporotic Fracture.