Bookedited by Alexander Choukèr.
Summary: This book explains how stress - either psychological or physical - can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors - the space exposome - on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters "The Impact of Everyday Stressors on the Immune System and Health", "Stress and Radiation Responsiveness" and "Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Contents:
Part I Prelude
1 Space Travel: A Personal View from Above
2 Prelude: An integrative and up-dated view from the Scientists of the Topical Team "Stress and Immunity"
Part II "Stress and Immunity"
Research: A Link Between Space and Earth
3 What Is Stress?
4 The special relation of mitochondria, metabolism and stress
5 The Impact of Everyday Stressors on the Immune- System and Health
Part III Stress and Immune Allostasis in Space, from Brain to Immune Responses
6 Neurobiological and Molecular Mechanisms of Stress and Glucocorticoid Effects on Learning and Memory: Implications for Stress Disorders on Earth and in Space
7 The Autonomic Nervous System
8 Circadian Rhythm and Stress
9 Endocannabinoids, "New-Old" Mediators of Stress Homeostasis
10 Immune System in Space: General Introduction and Observations on Stress-Sensitive Regulations
11 Innate Immunity Under Conditions of Space Flight
12 NK Cells Assessments: A Fourty-Year-Old History of Immune Stress Interaction in Space
13 Adaptive Immunity and Spaceflight
14 B-cell Immunology in Space
15 Stress, Hypoxia, and Immune Response
16 Gravitational Force: Triggered Stress in Cells of the Immune System
17 Microbial Stress: Spaceflight-induced Alterations in Microbial Virulence and Infectious Disease Risks for the Crew
18 Stress, Spaceflight, and Latent Herpes Virus Reactivation
19 Stress and Radiation-Immune-Responsiveness
Part IV Preventive and Diagnostic Tool and Strategies
20 Considerations for Development and Application of Health Monitoring Tools in Space
21 Psychological Monitoring
22 Technology up-date for monitoring Autonomic Activity
23 Breath Gas Analysis
24 Monitoring the Microbial Burden in Manned Space Stations and Analogue environments
25 Monitoring of Body Core Temperature in Space
26 Flow Cytometry and cryopreservation Methods to Monitor Immune Dysregulation Associated with Spaceflight
27 Assessment of Rad iosensitivity and Monitoringof Radiation-Induced Cellular Damage
28 Hair analyses
growing evidence
Part V Therapeutic Strategies
29 Considerations for Preventive and Therapeutic Strategies
30 Psychological Countermeasures
31 Physical Countermeasures to Stress
32 Nutritional Countermeasures for Spaceflight-Related Stress
33 The Microbiome perspective: Immune
gut- axis modulation
34 Pharmacological Countermeasures to Spaceflight-Induced Alterations of the Immune System
Part VI Perspectives for Manned Space Exploration
from Visions to Realities
35 Platforms for Stress and Immune Research in Preparation of Long-Duration Space Exploration Missions
36 MARS500 the first preparation of Long-Duration Space Exploration Missions
lessons learned for space exploration and health on Earth
37 On the ICE: Isolated, Confined and Extreme Environment
39 Moon, Mars and Beyond- the exploration roadmap and further visions.