BookMartin Zinkernagel, Chantal Dysli.
Summary: This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.
Contents:
Intro; Foreword; Contents; Abstract; Introduction; Methods; Results and Discussion; Conclusion; Abbreviations;
Chapter 1: Introduction; References;
Chapter 2: FLIO Technique and Principles; References;
Chapter 3: FLIO Historical Background; References;
Chapter 4: Fluorescence Lifetime Imaging Microscopy; References;
Chapter 5: The Fluorescence Lifetime Imaging Ophthalmoscope; References;
Chapter 6: Image Acquisition and Analysis; FLIO Reader; FLIMX; Supplementary Material; FLIO Image Acquisition Protocol; Subjects; Measurement; Preparation; Before Image Acquisition; During Measurement End of AcquisitionReferences;
Chapter 7: Fluorophores in the Eye; Introduction; Lipofuscin (Bisretinoids); Xantophyll (Yellow Carotinoids): Macular Pigment; Collagen/Elastin; Redox Coenzyme; Melanin/Oxidized Melanin; Lipid Peroxidation Endproducts; Advanced Glycation Endproducts (AGE); Other Fluorophores; References;
Chapter 8: FLIO in the Healthy Eye; References;
Chapter 9: FLIO in Retinal Diseases; References;
Chapter 10: Age-Related Macular Degeneration; FLIO in Early Disease Stages of AMD; FLIO in AMD with Drusen; FLIO in Geographic Atrophy; References
Chapter 11: FLIO in Diabetic RetinopathyReferences;
Chapter 12: Retinal Artery Occlusion; References;
Chapter 13: Central Serous Chorioretinopathy; References;
Chapter 14: Macular Telangiectasia Type 2; References;
Chapter 15: Hereditary Retinal Diseases: Stargardt, Choroideremia, Retinitis Pigmentosa; Stargardt Disease; Choroideremia; Retinitis Pigmentosa; References;
Chapter 16: Macular Pigment; Retinal Carotenoids; Carotenoid Measurement Ex Vivo; Macular Holes; Albinism; References;
Chapter 17: Fluorescence Lifetime Imaging Ophthalmoscopy in Alzheimer's Disease; References
Chapter 18: FLIO in Mouse ModelsReferences;
Chapter 19: Discussion and Summary; Index