BookJohng S. Rhim, Anatoly Dritschilo, Richard Kremer, editors.
Contents:
Intro; Preface; Acknowledgments; Contents; Part I: Mechanisms of Tumor Progression; Mechanisms Underlying Metastatic Pancreatic Cancer; PDAC Metastasis and Outcomes; Models of Metastasis; Genetically Engineered Mouse Models of Metastatic PDAC; Orthotopic Models of Pancreatic Cancer Metastasis; Mechanisms of Metastasis; EMT-MET Axis and Cellular Plasticity; Metastatic Organotropism: The Role of Exosomes and EMT Modulators; Epigenetic and Post-Transcriptional Regulators of EMT and Metastasis; Concluding Remarks; References; Current Perspectives on Nasopharyngeal Carcinoma; Introduction Historic PerspectiveCurrent Perspectives; Epidemiology; Incidence Rate; Impact of Human Migration on NPC Incidents; Risk Factors; Epstein Barr Virus (EBV); Single Nucleotide Polymorphisms (SNPs); Intake of Certain Foods; Model System for Investigating Nasopharyngeal Carcinoma; Potential Use of Zebrafish for Modeling Human NPC; Immunotherapy for Nasopharyngeal Carcinoma; Immunotherapy: General Concepts; Relevant Cancer Mouse Models for Preclinical Investigation of Immunotherapy; Immunotherapeutic Approaches for Cancer Treatment; Immunotherapy in NPC; Concluding Remarks; References An In Vitro Model of Triple-Negative Breast Cancer17€-Estradiol Induces Transformation and Tumorigenesis in Human Breast Epithelial Cells; Epithelial to Mesenchymal Transition in Human Breast Epithelial Cells Transformed by 17-Beta-Estradiol; Developing a Unique Model of Triple Negative Breast Cancer; Chromatin Remodeling During Human Breast Epithelial Cell Transformation; Concluding Remarks; References; Emerging Role of Novel Biomarkers of Ly6 Gene Family in Pan Cancer; Introduction; Expression of Ly6D, E, H, and K Genes in Normal Tissues; Ly6D; Ly6E; Ly6H; Ly6K Expression of Ly6D, E, H, and K Genes in Tumor TissuesLy6D; Ly6E; Ly6H; Ly6K; Mechanisms Associated Ly6D, E, H, and K Gene Family; Ly6D; Ly6E; Ly6H; Ly6K; Summary; References; The Oncoprotein Gankyrin/PSMD10 as a Target of Cancer Therapy; Isolation of Gankyrin from Hepatocellular Carcinoma; Enhanced Degradation of RB (Retinoblastoma-Associated Protein) and p53 (Cellular Tumor Antigen p53) by Gankyrin; Gankyrin as a Killer of Multiple Tumor Suppressor Proteins; Animal Models Overexpressing Gankyrin in the Liver Importance of Non-Parenchymal Cells in Carcinogenesis as Demonstrated by Gankyrin-Knockout MiceGankyrin as a Promising Therapeutic Target; Experimental Anti-Gankyrin Agents; Conclusion; References; Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis; Introduction; Updated Mechanisms of Ethanol-Mediated Carcinogenesis; Contributing Roles of CYP2E1 and Other P450 Isoforms in Tissue Injury and Cancer Development; Multiple Regulations of CYP2E1 and Alcohol-Related Tissue Injury and Carcinogenesis Distribution of CYP2E1 and Carcinogenesis in Extra-Hepatic Tissues