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  • Book
    Suzanne D. Dixon, Martin T. Stein.
    Contents:
    Perspectives on child development in child health care / Suzanne D. Dixon and Martin T. Stein
    Understanding children: theories, concepts and insights / Suzanne D. Dixon
    Cultural dimensions in child care / Lori Taylor, Lyndia Willes-Jacobo and Suzanne D. Dixon
    Developmentally based office: setting the stage for enhanced practice / Martin T. Stein
    Use of drawing by children at health encounters / John B. Welsh, Susan L. Instone and Martin T. Stein
    The prenatal visit: making an alliance with the family / Suzanne D. Dixon
    The newborn: ready to get going / Suzanne D. Dixon
    Neonatal intensive care units: special issues for the at-risk infant and family / Suzanne D. Dixon and Yvonne E. Vaucher
    First days at home: making a place in the family / Suzanne D. Dison and Martin T. Stein
    One to two months: getting on track / Martin T. Stein
    Three to four months: having fun with the picture book baby / Suzanne D. Dixon
    Six months: reaching out / Suzanne D. Dixon and Michael J. Hennessy. Eight to nine months: exploring and clinging / Maria Trozzi and Suzanne D. Dixon
    One year: one giant step forward / Suzanne D. Dixon and Michael J. Hennessy
    15 to 18 months: declaring independence and pushing the limits / Maria Trozzi and Martin T. Stein
    Two years: language leaps / Suzanne D. Dixon
    Three years: emergence of magic / Suzanne D. Dixon
    Four years: clearer sense of self / Suzanne D. Dixon
    Five years: opening the school door / Martin T. Stein
    Six to seven years: reading, relationships and playing by the rules / Martin T. Stein
    Seven to ten years: the world of middle childhood / Robert David Wells and Martin T. Stein
    Eleven to fourteen years: early adolescence
    age of rapid changes / Jennifer Maehr and Marianne E. Felice
    Fifteen to seventeen years: mid-adolescence-redefining self / Jennifer Maehr and Marianne E. Felice
    Seventeen to twenty-one years: transition to adulthood / Lawrence S. Friedman
    Special families / Robert David Wells and Martin T. Stein
    Encounters with illness: coping and growing / Martin T. Stein
    Stressful events: separation, loss, violence and death / Maria Trozzi and Suzanne D. Dixon
    Resources for families: an annotated bibliography / Martin T. Stein and Suzanne D. Dixon.
    Digital Access ScienceDirect 2006
  • Article
    Mandelli M, Tognoni G, Garattini S.
    Clin Pharmacokinet. 1978 Jan-Feb;3(1):72-91.
    Diazepam is still one of the most used of the benzodiazepine group of drugs. Extensive studies over 10 years have defined a fairly complete profile of its kinetics. Minor aspects relating to patterns of its metabolism and excretion in certain age groups and in some disease states remain to be described quantitatively. However, there is more than sufficient kinetic information available for the requirements of good clinical practice. For optimum clinical benefit with minimum side-effects the following kinetic properties should be borne in mind: (a) there is a large interindividual variation (up to 30-fold) in dose/blood level ratios, especially when treatment is short-term; (b) the elimination half-life is prolonged in the elderly and the newborn and in some cases of liver disease; (c) there is accumulation of the active N-desmethylated metabolite during long-term treatment; and (d) administration of diazepam to pregnant women leads to rapid distribution from the maternal to fetal compartment: accumulation of both diazepam and desmethyldiazepam could cause prolonged sedation in the newborn. As there does not appear to be any clear relationship between the concentration of diazepam in the plasma and clinical effect, measurement of blood levels, other than for research purposes, is unnecessary. Based on kinetic data, a single administration of diazepam at night should be adequate for hypnotic and anxiolytic effects in most patients.
    Digital Access Access Options