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  • Book
    Paolo Sbraccia, Nicholas Finer, editors.
    Summary: This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obesity, including an ever -increasing number of other diseases such as type 2 diabetes, cardiovascular diseases and cancer, as well as conditions such as arthropathy, asthma, non-alcoholic liver disease, and dementia. Increasingly recognized uniting causes highlight the role of systemic, local and paracrine actions of adipocytokines in causing inflammation. As we come to better understand how hypothalamic control of energy balance is influenced by endocrine signaling from the gut and adipose tissue, it paves the way for new therapeutic targets and a resurgence of pharmacological and surgical approaches to treatment. Written by respected experts in the field, this volume is intended as a major reference source for endocrinologists, nutritionists, basic and clinical scientists alike.

    Epigenetics and fetal programming
    Neuroendocrinology of energy balance
    The adipose organ
    Role of gut hormones
    Environmental factors: pollutants, viruses food
    Food, metabolism and longevity
    The microbiota and energy balance
    Eating disorders
    Clinical assessment of the patient with overweight or obesity
    Obesity and NAFLD
    Obesity and type 2 diabetes
    Obesity and hypertension
    Obesity and dyslipidemia
    Obesity and obstructive sleep apnoea syndrome
    Impact of obesity on cardiovascular disease
    Obesity and psychiatry
    Obesity in Children
    Dietary treatment
    Physical exercise
    Cognitive and behavioral approaches
    Pharmacological approaches
    Surgical approaches
    An integrated view of treatment options.
    Digital Access Springer 2019