Bookedited by Swapan K. Ray.
Summary: "Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions"--Publisher's description.
Contents:
Neuroblastoma pathology and classification
Role of genetic and epigenetic alterations in pathogenesis of neuroblastoma
Neuroblastoma molecular biology and promising therapeutic targets
The GD2-targeted immunotherapy of neuroblastoma
Targeting angiogenesis in neuroblastoma
Autophagy and novel therapeutic strategies in neuroblastoma
Energy metabolism and new therapeutic opportunities in neuroblastoma
Multimodality imaging for diagnosis of neuroblastoma
Immunotherapy for neuroblastoma
Advances in surgical treatment of neuroblastoma
Role of stemness factors in neuroblastoma: Neuroblastoma stem cells, tumor microenvironment, and chemoresistance
Current pharmacotherapy for neuroblastoma
Current challenges in the management of neuroblastoma
Novel therapeutic targets in neuroblastoma
Current and future strategies for treatment of relapsed neuroblastoma
Current evidence in favor of a tumor suppressor role of Krüppel-like factor 4 in malignant neuroblastoma
Modulation of expression of microRNA as a therapeutic strategy in malignant neuroblastoma.