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- Bookedited by Eric G. Schmuck, Peiman Hematti, Amish N. Raval.Summary: This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM's role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.
Contents:
Biomechanical properties and mechanobiology of cardiac ECM / Michael Nguyen-Truong, Zhijie Wang
Imaging the cardiac extracellular matrix / Michael A. Pinkert, Rebecca A. Hortensius, Brenda M. Ogle, Kevin W. Eliceiri
Animal models and cardiac extracellular matrix research / Timothy A. Hacker
Applications of cardiac extracellular matrix in tissue engineering and regenerative medicine / Mark C. Daley, Spencer L. Fenn, Lauren D. Black III
Whole cardiac tissue bioscaffolds / Karis R. Tang-Quan, Nicole A. Mehta, Luiz C. Sampaio, Doris A. Taylor
Natural sources of extracellular matrix for cardiac repair / Keith L. Spinali, Eric G. Schmuck
Cardiac extracellular matrix modification as a therapeutic approach / Mikayla L. Hall, Brenda M. Ogle
Extracellular matrix for myocardial repair / Jenna L. Dziki, Stephen F. Badylak
Role of extracellular matrix in cardiac cellular therapies / Peiman Hematti
Regulation of regenerative medicine products / Adrian P. Gee
Clinical trial design for investigational cardio-regenerative therapy / Amish N. Raval
Regenerative medicine venturing at the university-industry boundary: implications for institutions, entrepreneurs, and industry / Adam J. Bock, David Johnson. - ArticleAust Nurses J. 1977 Oct;7(4):15-6.