BookDaniela Galimberti, Elio Scarpini, editors.
Summary: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, Lewy body dementia, Parkinson's disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Contents:
Chapter 1. Genetics and epigenetics in the neurodegenerative disorders of the central nervous system
Chapter 2. Diagnosis of Alzheimer's disease typical and atypical forms
Chapter 3. Genetic complexity of early-onset Alzheimer's disease
Chapter 4. Genetic risk factors for complex forms of Alzheimer's disease
Chapter 5. Role of cerebrovascular disease in cognition
Chapter 6. Risk factors and prevention in Alzheimer's disease and dementia
Chapter 7. Diagnosis of frontotemporal dementia
Chapter 8. Autosomal dominant frontotemporal lobar degeneration: from genotype to phenotype
Chapter 9. Genetic risk factors for sporadic frontotemporal dementia
Chapter 10. Alzheimer's disease and frontotemporal lobar degeneration: mouse models
Chapter 11. Fluid biomarkers in Alzheimer's disease and frontotemporal dementia
Chapter 12. Biomarkers for Alzheimer's disease and frontotemporal lobar degeneration: imaging
Chapter 13. Genotypic and phenotypic heterogeneity in Amyotrophic lateral sclerosis
Chapter 14. Lewy body dementia
Chapter 15. Rare dementias
Chapter 16. Neurodevelopmental and neurodegenerative alterations in the pathophysiology of schizophrenia: focus on neuro-immuno-inflammation
Chapter 17. Parkinson's disease: contemporary concepts and clinical management
Chapter 18. Neurodegeneration and multiple sclerosis.