BookLinqi Zhang, Sharon R. Lewin, editors.
Summary: "This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry"--Publisher's description.
Contents:
HIV vaccines. HIV vaccine efficacy trials: RV144 and beyond / Elizabeth Heger, Alexandra Schuetz, Sandhya Vasan
HIV T-cell vaccines / Beatriz Mothe, Christian Brander
HIV broadly neutralizing antibodies: VRC01 and beyond / Xueling Wu
Structural features of broadly neutralizing antibodies and rational design of vaccine / Tongqing Zhou, Kai Xu
Monkey models and HIV vaccine research / Zhiwei Chen
Treatment of HIV for the prevention of transmission in discordant couples and at the population level / M. Kumi Smith, Britta L. Jewell, Timothy B. Hallett, Myron S. Cohen
HIV cure. HIV persistence on antiretroviral therapy and barriers to a cure / Julia Marsh Sung, David M. Margolis
The molecular biology of HIV latency / Georges Khoury, Gilles Darcis, Michelle Y. Lee, Sophie Bouchat, Benoit Van Driessche, Damian F. J. Purcell [and others]
Cellular determinants of HIV persistence on antiretroviral therapy / Anastassia Mikhailova, Jose Carlos Valle-Casuso, Asier Sáez-Cirión
In vitro and in vivo models of HIV latency / James B. Whitney, R. Brad Jones
Measuring HIV persistence on antiretroviral therapy / Bethany A. Horsburgh, Sarah Palmer
Clinical interventions in HIV cure research / Thomas Aagaard Rasmussen, Ole S. Søgaard.