BookJosé A. Horcajadas, Jaime Gosálvez.
Summary: Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The -Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine.
Contents:
Front Matter
Copyright
Contributors
Preface
Introduction: Human Genome Projects: The Omics Starting Point
Is the Classic Spermiogram Still Informative? How Did It Develop and Where Is It Going?
Genetic Variations and Male Infertility
New Genetic Point Mutations in Male Infertility
Carrier Screening for Inherited Genetic Disorders: A Review of Current Practices
Telomeres in Germ Line and Early Embryo: An Overview
Human Protamine Genes' Polymorphisms as a Possible Cause Underlying Male Infertility
Small RNAs Present in Semen and Their Role in Reproduction
Altered Transcriptomic Profiles Associated With Male Infertility
Proteomics and Metabolomics Studies and Clinical Outcomes
Epigenetics, Spermatogenesis, and Male Infertility
Changes in DNA Methylation Related to Male Infertility
Noninvasive Methods of Embryo Selection
Genetic Selection of the Human Embryos: From FISH to NGS, Past and Future
Unraveling the Causes of Failed Fertilization After Intracytoplasmic Sperm Injection Due to Oocyte Activation Deficiency
The Molecular Signature of the Endometrial Receptivity: Research and Clinical Application
The Acquisition of the Human Endometrial Receptivity Phenotype: Lessons From Proteomic Studies
Stem Cell-Derived Spermatozoa
Computational Approaches in Reproductomics
Conclusions--Year 2020: The “-Omics” Technologies and Personalized Assisted Reproduction
Index