Bookedited by Leonard Guarente, Raul Mostoslavsky, Alaksey Kazantsev.
Summary: Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.
Contents:
Chapter 1. Sirtuins, NAD+, Aging, and Disease: A Retrospective and Prospective Overview / Leonard Guarente
Chapter 2. Regulation of Sirtuins by Systemic NAD+ Biosynthesis / Mitsukuni Yoshida, Shin-ichiro Imai
Chapter 3. NAD+ Modulation: Biology and Therapy / Elena Katsyuba, Johan Auwerx
Chapter 4. The Enzymatic Activities of Sirtuins / Hening Lin
Chapter 5. Structural and Mechanistic Insights in Sirtuin Catalysis and Pharmacological Modulation / Sébastien Moniot, Weijie You, Clemens Steegborn
Chapter 6. Pharmacological Approaches for Modulating Sirtuins / Alice E. Kane, David A. Sinclair
Chapter 7. Reactive Acyl-CoA Species and Deacylation by the Mitochondrial Sirtuins / Kathleen A. Hershberger, Matthew D. Hirschey
Chapter 8. Mitochondrial Sirtuins: Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks / Wen Yang, Robert A.H. van de Ven, Marcia C. Haigis
Chapter 9 - Multitasking Roles of the Mammalian Deacetylase SIRT6 / Sylvana Hassanieh, Raul Mostoslavsky
Chapter 10. Chromatin and Nuclear Signaling: SIRT7 Function in the Nucleolus and Beyond / Maria Angulo-Ibanez, Katrin F. Chua
Chapter 11. Mammalian Sirtuins, Cellular Energy Regulation, and Metabolism, and Carcinogenesis / Athanassios Vassilopoulos, Rui-Hong Wang, David Gius
Chapter 12. Roles for Sirtuins in Cardiovascular Biology / Adam B. Stein, William Giblin, Angela H. Guo, David B. Lombard
Chapter 13. Sirtuins in Brain and Neurodegenerative Disease / Éva M. Szegő, Tiago F. Outeiro, Aleksey G. Kazantsev.