Book[edited by] Laurence J.N. Cooper, Elizabeth A. Mittendorf, Judy Moyes, Sabitha Prabhakaran.
Summary: "Immunotherapy in Translational Cancer Research is a volume in Translational Oncology, an exciting book series that focuses on translational cancer research. Immunotherapy has become a key aspect in the treatment of a wide variety of cancers, and this book is specifically designed for physicians, clinical fellows, medical students, graduate students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists. Each chapter is consistently organized and features three essential themes: Development of the immunotherapy; Hurdles that were overcome to scale up and undertake clinical trials; and Clinical experience and application of research. Concepts, examples and alternative strategies to achieve individualized targeted therapy are presented, with thorough consideration of the relevant history, current state and future directions of emerging cancer-fighting therapies, drug development, clinical trials, and governmental resources and regulatory issues."--Provided by publisher.
Contents:
1. Translation in immunology: the role of translational biomarkers to guide clinical use of immunotherapy for cancer
2. Monoclonal antibody therapy
3. Somatic mutations and immunotherapy
4. Checkpoint blockade
5. Myeloid leukemia vaccines
6. Cancer vaccines for solid tumors
7. Immunotherapy with non-genetically modified T cells
8. Immunotherapy with genetically modified T cells
9. Immunomodulations with adjuvants and cytokines
10. Immune cell migration in cancer and immunotherapy
11. Repurposing of drugs for immunotherapy
12. Immunomodulation with radiation
13. Good manufacturing practices facilities for cellular therapy
14. T Cell receptor mimic antibodies
15. Stem cell transplantation for treatment of malignancy
16. Natural killer cell-based immunotherapy
17. Immunologic monitoring in immuno-oncology
18. Cell-based therapies for canine cancer
19. Interaction between targeted therapy and immunotherapy
Index.