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  • Book
    Parakrama T. Chandrasoma.
    Summary: GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible.

    Contents:
    Definition of gastroesophageal reflux disease
    Present diagnosis and management of gastroesophageal and reflux disease
    Fetal and postnatal development of the esophagus and proximal stomach
    Histologic definition and diagnosis of epithelia in the esophagus and proximal stomach
    Definition of the normal state
    Definition of the gastroesophageal junction
    The normal lower esophageal sphincter
    The pathogenesis of early GERD
    Correlation of LES damage and GERD
    The effect of damage to the abdominal segement of the LES
    Columnar-lined esophagus
    Esophageal adenocarcinoma
    Progression of GERD at the clinical level
    Progression of GERD at a pathological level
    Molecular evolution of esophageal epithelial metaplasia
    Progression of GERD from the perspective of LES damage
    New pathologic test of LES damage
    New method of functional assessment of the LES
    Prediction of future progression of LES damage
    Proof of cencept of the new diagnostic method
    Application of the new method to present and future management of GERD.
    Digital Access ScienceDirect 2018
  • Book
    a cura di Antonino Buttitta ; testi di G. Aiello ... [et al.] ; redazione e bibliografia di Mario Giacomarra ; documentazione fotografica a cura di Girolamo Cusimano.
    Print c1988
  • Article
    Gelston AL, Jones TC.
    J Infect Dis. 1977 Dec;136(6):813-21.
    An epidemic of thyphus fever in New York City in 1847 that was associated with massive immigrations from Ireland is described by review of the records of 138 cases admitted to The New York Hospital during a seven-week period. Medical understanding of epidemic diseases, of typhus, and of therapeutics is examined. Most patients (80%) acquired the disease during passage, but 20% of the cases resulted from secondary spread in New York. The illness was characterized by high fever, headache, myalgias, and loss of appetite. Complications, most commonly central nervous system dysfunction and secondary bacterial infections, occurred in 29% of the cases. The mortality rate was 11%. Therapy was directed at cleansing the bowel and diaphoresis. Bleeding was not employed. In spite of mistaken concepts about epidemic diseases, measures were employed that controlled spread of the disease.
    Digital Access Access Options