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    editor-in-chief, David Feldman, senior associate editor, J. Wesley Pike, associate editors, Roger Bouillon, Edward Giovannucci, David Goltzman, Martin Hewison.
    Summary: "Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description.

    Contents:
    Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d
    Evolutionary biology: mysteries of vitamin D in fish
    Evolution of human skin color and vitamin D
    Photobiology of vitamin D
    The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases)
    CYP24A1: structure, function, and physiological role
    The vitamin D binding protein DBP
    Regulation of renal and extra-renal 1[alpha]-hydroxylase
    Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells
    Diverse mechanisms of transcriptional regulation by the vitamin D receptor
    Structural basis for ligand activity in VDR
    Ligand independent actions of vitamin D receptor
    Vitamin D and chromatin
    Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR
    Vitamin D and microRNAs
    Vitamin D sterol/VDR conformational dynamics and nongenomic actions
    Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function
    Osteoclastogenesis and vitamin D
    Vitamin D activities in osteocytes
    Regulation of intestinal calcium and phosphate absorption
    Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6
    Calcium homeostasis and eggshell biomineralization in female chicken
    Mineralization in mammals
    Cartilage
    Vitamin D and bone: an integrated approach
    Section IV. Extra-skeletal targets. Vitamin D and the kidney
    Vitamin D and the parathyroids
    The calcium-sensing receptor and vitamin d
    Vitamin D in dentoalveolar and oral health
    The role of vitamin D and its receptor in hair follicle biology
    Vitamin D, calcium and the epidermis
    Vitamin D and the cardiovascular system
    Vitamin D brain development and function
    Vitamin D, VDR and adipose tissue: focus on cellular mechanisms
    Vitamin D and skeletal muscle
    Understanding vitamin D from mouse knockout models
    Section V. Human physiology. Pharmacology and pharmacokinetics
    Vitamin D role in the calcium and phosphorus economies
    Fetus, neonate and infant
    Consequences of perinatal vitamin D deficiency on later bone health
    Adolescence and acquisition of peak bone mass
    Pregnancy, lactation, and post-weaning recovery
    Role in reproductive biology and reproductive dysfunction in women
    Vitamin d, reproductive biology, and dysfunction in men
    Vitamin D and the renin-angiotensin system
    Parathyroid hormone, parathyroid hormone-related protein, and calcitonin
    FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity
    Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease
    Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology
    Mass spectrometry assays of vitamin D metabolites
    Free vitamin d: concepts, assays, outcomes and prospects
    25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation
    Bone histomorphometry
    Radiology of rickets and osteomalcia
    High-resolution imaging techniques for bone quality assessment
    The role of vitamin D in orthopedic surgery
    The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position
    The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position
    Digital Access
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    ScienceDirect
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    Books: General Collection (Downstairs)
    RC648 .V83 2018
    1