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  • Book
    edited by Andrew S. Feigin and Karen E. Anderson
    Summary: "Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington's disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource"--Publisher's description.

    Contents:
    Section 1: Basic science. Genetics of Huntington disease
    Mechanisms underlying neurodegeneration in Huntington disease: Applications to novel disease-modifying therapies
    Section 2: Clinical aspects. Epidemiology of Huntington disease
    Statistical modelling of Huntington disease onset
    The diagnosis and natural history of Huntington's disease
    Preclinical cognitive and behavioral changes in Huntington disease
    Preclinical motor manifestations of Huntington disease
    The highly anxious individual presenting for Huntington disease predictive genetic testing: the psychiatrist's role in assessment and counseling
    Reproductive options for Huntington disease families
    Genetic testing for Huntington disease
    Section 3: Treatment of Huntington disease. Medical treatment of behavioral manifestations of Huntington disease
    Medical management of motor manifestations of Huntington disease
    The role of rehabilitation therapy in Huntington disease
    Contemporary health care for Huntington disease
    The impact of Huntington disease on young people
    Making a measurable difference in advanced Huntington disease care
    Section 4: Experimental Therapeutics. New symptomatic therapies for Huntington disease
    Motor outcome measures in Huntington disease clinical trials
    Cognitive outcome measures in Huntington disease clinical drug trials
    Section 5: Biomarkers. Structural imaging in premanifest and manifest Huntington disease
    Functional imaging in Huntington disease.
    Digital Access ScienceDirect 2017
  • Article
    Wermuth BM, Davis KL, Hollister LE, Stunkard AJ.
    Am J Psychiatry. 1977 Nov;134(11):1249-53.
    Nineteen subjects completed a 12-week double-blind crossover study comparing phenytoin with placebo in the treatment of severe binge eating. In the placebophenytoin sequence the number of binges decreased during phenytoin treatment from both placebo and pretreatment levels. However, in the phenytoin-placebo sequence, not only did phenytoin reduce the number of binges from pretreatment levels, but there was no reversal of this effect during the placebo period. This sequential effect was unexpected and is still unexplained. The mechanism of phenytoin action and the significance of EEG abnormalities found in 7 of the subjects remain uncertain.
    Digital Access Access Options