Bookedited by Andrew S. Feigin and Karen E. Anderson
Summary: "Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington's disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource"--Publisher's description.
Contents:
Section 1: Basic science. Genetics of Huntington disease
Mechanisms underlying neurodegeneration in Huntington disease: Applications to novel disease-modifying therapies
Section 2: Clinical aspects. Epidemiology of Huntington disease
Statistical modelling of Huntington disease onset
The diagnosis and natural history of Huntington's disease
Preclinical cognitive and behavioral changes in Huntington disease
Preclinical motor manifestations of Huntington disease
The highly anxious individual presenting for Huntington disease predictive genetic testing: the psychiatrist's role in assessment and counseling
Reproductive options for Huntington disease families
Genetic testing for Huntington disease
Section 3: Treatment of Huntington disease. Medical treatment of behavioral manifestations of Huntington disease
Medical management of motor manifestations of Huntington disease
The role of rehabilitation therapy in Huntington disease
Contemporary health care for Huntington disease
The impact of Huntington disease on young people
Making a measurable difference in advanced Huntington disease care
Section 4: Experimental Therapeutics. New symptomatic therapies for Huntington disease
Motor outcome measures in Huntington disease clinical trials
Cognitive outcome measures in Huntington disease clinical drug trials
Section 5: Biomarkers. Structural imaging in premanifest and manifest Huntington disease
Functional imaging in Huntington disease.